Gas-solid fluidized beds have drawn the attention of engineers and researchers as an
effective technology for a large variety of applications, and numerical simulations can play …

The effective implementation of Quality by Design (QbD) for wet granulation requires
quantitative models for design and scaling of granulators. This paper reviews that current …

Fluid flows with cohesive particles are present in oil industry (eg natural gas/oil with
hydrates, wax or asphaltenes), medicine (eg blood cells), nano-and ferro-fluidic applications …

This paper addresses fluid-bed melt granulation (FBMG) for seeds and a binder of the same
chemical nature, ie with an identical melting point. The purpose of this work is to study the …

In the present work, the multiphase flow dynamics in fluidized beds is modelled using the
Two-Fluid Model (TFM) where the characteristics of a granular solid phase are described by …

Mass and population balance equations are used to describe the spray-on melt granulation
process in a batch fluidized bed where coating and agglomeration can occur …

A Wurster fluidized bed, widely used in the coating process of the pharmaceutical industry, is
modeled to investigate the characteristics of gas-solids flow, concerning the effect of Wurster …

Tablets are the most customarily used solid oral unit dosage form for its better patient
compliance. Preparation of these tablets include granulation, granule drying, die filling, and …

This work elucidates the fundamental concepts that are essential to understand fluidized
bed agglomeration and reviews the development of tools used to predict it. The process of …

This paper presents a predictive aggregation rate model for spray fluidized bed melt
granulation. The aggregation rate constant was derived from probability analysis of particle …