[HTML][HTML] Structure, dynamics and function of the 26S proteasome
Y Mao - Macromolecular protein complexes III: structure and …, 2021 - Springer
The 26S proteasome is the most complex ATP-dependent protease machinery, of~ 2.5 MDa
mass, ubiquitously found in all eukaryotes. It selectively degrades ubiquitin-conjugated …
mass, ubiquitously found in all eukaryotes. It selectively degrades ubiquitin-conjugated …
Proteasome substrate receptors and their therapeutic potential
V Osei-Amponsa, KJ Walters - Trends in biochemical sciences, 2022 - cell.com
The ubiquitin-proteasome system (UPS) is critical for protein quality control and regulating
protein lifespans. Following ubiquitination, UPS substrates bind multidomain receptors that …
protein lifespans. Following ubiquitination, UPS substrates bind multidomain receptors that …
Proteasome interaction with ubiquitinated substrates: from mechanisms to therapies
The 26S proteasome is responsible for regulated proteolysis in eukaryotic cells. Its
substrates are diverse in structure, function, sequence length, and amino acid composition …
substrates are diverse in structure, function, sequence length, and amino acid composition …
[HTML][HTML] hRpn13 shapes the proteome and transcriptome through epigenetic factors HDAC8, PADI4, and transcription factor NF-κB p50
The anti-cancer target hRpn13 is a proteasome substrate receptor. However, hRpn13-
targeting molecules do not impair its interaction with proteasomes or ubiquitin, suggesting …
targeting molecules do not impair its interaction with proteasomes or ubiquitin, suggesting …
Mechanisms of substrate recognition by the 26S proteasome
C Davis, BL Spaller, A Matouschek - Current opinion in structural biology, 2021 - Elsevier
Highlights•Many types of ubiquitin modification can target proteins to the proteasome for
degradation.•The ubiquitin receptors of the RP individually and cooperatively function to …
degradation.•The ubiquitin receptors of the RP individually and cooperatively function to …
Branched ubiquitin chain binding and deubiquitination by UCH37 facilitate proteasome clearance of stress-induced inclusions
A Song, Z Hazlett, D Abeykoon, J Dortch, A Dillon… - Elife, 2021 - elifesciences.org
UCH37, also known as UCHL5, is a highly conserved deubiquitinating enzyme (DUB) that
associates with the 26S proteasome. Recently, it was reported that UCH37 activity is …
associates with the 26S proteasome. Recently, it was reported that UCH37 activity is …
[HTML][HTML] Structure-guided bifunctional molecules hit a DEUBAD-lacking hRpn13 species upregulated in multiple myeloma
Proteasome substrate receptor hRpn13 is a promising anti-cancer target. By integrated in
silico and biophysical screening, we identified a chemical scaffold that binds hRpn13 with …
silico and biophysical screening, we identified a chemical scaffold that binds hRpn13 with …
[HTML][HTML] Mechanism of activation and regulation of deubiquitinase activity in MINDY1 and MINDY2
Of the eight distinct polyubiquitin (polyUb) linkages that can be assembled, the roles of K48-
linked polyUb (K48-polyUb) are the most established, with K48-polyUb modified proteins …
linked polyUb (K48-polyUb) are the most established, with K48-polyUb modified proteins …
[HTML][HTML] A structure-based designed small molecule depletes hRpn13Pru and a select group of KEN box proteins
Proteasome subunit hRpn13 is partially proteolyzed in certain cancer cell types to generate
hRpn13Pru by degradation of its UCHL5/Uch37-binding DEUBAD domain and retention of …
hRpn13Pru by degradation of its UCHL5/Uch37-binding DEUBAD domain and retention of …
[HTML][HTML] Proteasome inhibition is an effective treatment strategy for microsporidia infection in honey bees
EM Huntsman, RM Cho, HV Kogan… - Biomolecules, 2021 - mdpi.com
The microsporidia Nosema ceranae is an obligate intracellular parasite that causes honey
bee mortality and contributes to colony collapse. Fumagillin is presently the only …
bee mortality and contributes to colony collapse. Fumagillin is presently the only …