RNA modifications have become hot topics recently. By influencing RNA processes,
including generation, transportation, function, and metabolization, they act as critical …

Aggregation of the microtubule-associated protein tau plays a major role in Alzheimer's
disease and several other neurodegenerative disorders. An exciting recent development is …

N6-methyladenosine (m6A) regulates mRNA metabolism. While it has been implicated in
the development of the mammalian brain and in cognition, the role of m6A in synaptic …

RNA binding proteins that act at the post-transcriptional level display a richness of
mechanisms to modulate the transcriptional output and respond to changing cellular …

Pathological tau aggregation is a primary neuropathological feature of many
neurodegenerative diseases. Intriguingly, despite the common presence of tau aggregates …

RNA methylation at adenosine N6 (m6A) is one of the most common RNA modifications,
impacting RNA stability, transport, and translation. Previous studies uncovered RNA …

Solid-like protein deposits found in aged and diseased human brains have revealed a
relationship between insoluble protein accumulations and the resulting deficits in neurologic …

Postmitotic neurons require persistently active controls to maintain terminal differentiation.
Unlike dividing cells, aberrant cell cycle activation in mature neurons causes apoptosis …

C9orf72 repeat expansions are the most common genetic cause of frontotemporal dementia
(FTD) and amyotrophic lateral sclerosis (ALS). Poly (GR) proteins are toxic to neurons by …

Abstract N6-methyladenosine (m6A) is a ubiquitous mRNA modification in eukaryotes. m6A
occurs through the action of methyltransferases, demethylases, and methylation-binding …