The present document has been conceived as the European update to the American
College of Cardiology (ACC)/American Heart Association (AHA)/ESC 2006 Guidelines for …

A unique and highly versatile technique, stress echocardiography (SE) is increasingly
recognized for its utility in the evaluation of non-ischaemic heart disease. SE allows for …

Background—Identifying hospitalized patients at risk for QT interval prolongation could lead
to interventions to reduce the risk of torsades de pointes. Our objective was to develop and …

Clozapine, a dibenzodiazepine developed in 1961, is a multireceptorial atypical
antipsychotic approved for the treatment of resistant schizophrenia. Since its introduction, it …

Method We searched PubMed for pertinent literature on the risk of QTc prolongation and/or
TdP associated with commonly used psychotropic drugs. Results Thioridazine and …

Anxiety symptoms can occur in up to 65% of patients with schizophrenia, and may reach the
threshold for diagnosis of various comorbid anxiety disorders, including obsessive …

Despite the limited availability of randomized, controlled evidence regarding the efficacy and
safety of second-generation antipsychotics (SGAs) in pediatric populations [1, 2], this class …

Psychotropics are among the most common causes of drug induced acquired long QT
syndrome. Blockage of Human ether-ago-go-related gene (HERG) potassium channel by …

Several antipsychotics are associated with the ventricular tachycardia torsade de pointes
(TdP), which may lead to sudden cardiac death (SCD), because of their inhibition of the …

Background Proarrhythmia assessment is one of the major concerns for regulatory bodies
and pharmaceutical industry. ICH guidelines recommending preclinical tests have been …