Mutations that decrease or increase the activity of the tyrosine phosphatase, SHP2 (encoded
by PTPN11), promotes developmental disorders and several malignancies by varying …

Adipocytes are derived from pluripotent mesenchymal stem cells and can develop into
several cell types including adipocytes, myocytes, chondrocytes, and osteocytes. Adipocyte …

Histone deacetylases (HDACs) are a class of zinc (Zn)-dependent metalloenzymes that are
responsible for epigenetic modifications. HDACs are largely associated with histone …

The Ataxia telangiectasia and RAD3-related (ATR) kinase is a key regulator of DNA
replication stress responses and DNA-damage checkpoints. Several potent and selective …

Simple Summary Tumors in the pancreas and colon are still too often an unmet clinical
problem. Cells from these cancers and normal cells have different gene expression profiles …

The FMS-like tyrosine kinase-3 (FLT3) is mutated in~ 30% of acute myeloid leukemia (AML)
patients. Common FLT3 mutations are internal tandem duplications (FLT3-ITD) and point …

Introduction Posttranslational modification of proteins by reversible acetylation regulates key
biological processes. Histone deacetylases (HDACs) catalyze protein deacetylation and are …

The characterization of epigenetic changes during cancer development and progression led
to notable insights regarding the roles of cancer-specific epigenetic reprogramming. Recent …

Secreted protein acidic and rich in cysteine (SPARC), a conserved secreted glycoprotein,
plays crucial roles in regulating various biological processes. SPARC is highly expressed …

Post-translational modifications of histones are important regulators of the DNA damage
response (DDR). By using affinity purification mass spectrometry (AP-MS) we discovered …