Streptococcus pyogenes, or Group A Streptococcus, is an exclusively human pathogen that
causes a wide variety of diseases ranging from mild throat and skin infections to severe …

Optimization of small-molecule probes or drugs is a synthetically lengthy, challenging, and
resource-intensive process. Lack of automation and reliance on skilled medicinal chemists …

Streptococcal pyrogenic exotoxin B (SpeB) is a cysteine protease expressed during group A
streptococcal infection that represents a major virulence factor. Although subject to several …

Here, we perform structural, thermodynamic, and kinetics tests of the Kirkwood–Buff-derived
force field, KBFF20, for peptides and proteins developed in the previous article. The …

Members of the CA class of cysteine proteases have multifaceted roles in physiology and
virulence for many bacteria. Streptococcal pyrogenic exotoxin B (SpeB) is secreted by …

Streptococcal cysteine protease (SpeB), the major secreted protease produced by group A
streptococcus (GAS), cleaves both host and bacterial proteins and contributes importantly to …

The secreted Streptococcus pyogenes cysteine protease SpeB is implicated in host immune
system evasion and bacterial virulence. We present a small molecule inhibitor of SpeB 2477 …

Background Actinidin, a protease from kiwifruit, belongs to the C1 family of cysteine
proteases. Cysteine proteases were found to be involved in many disease states and are …

Streptococcus pyogenes produces the cysteine protease streptopain (SpeB) as a critical
virulence factor for pathogenesis. Despite having first been described seventy years ago …

An important function of fungal lectins is to protect their host. Marasmius oreades agglutinin
(MOA) is toxic to nematodes and exerts its protective effect through protease activity. Its …