Immune cell-mediated features of non-alcoholic steatohepatitis

T Huby, EL Gautier - Nature reviews immunology, 2022 - nature.com
Non-alcoholic fatty liver disease (NAFLD) includes a range of hepatic manifestations,
starting with liver steatosis and potentially evolving towards non-alcoholic steatohepatitis …

The ménage à trois of autophagy, lipid droplets and liver disease

Y Filali-Mouncef, C Hunter, F Roccio, S Zagkou… - Autophagy, 2022 - Taylor & Francis
Autophagic pathways cross with lipid homeostasis and thus provide energy and essential
building blocks that are indispensable for liver functions. Energy deficiencies are …

[HTML][HTML] Dysregulated m6A modification promotes lipogenesis and development of non-alcoholic fatty liver disease and hepatocellular carcinoma

Y Yang, J Cai, X Yang, K Wang, K Sun, Z Yang… - Molecular Therapy, 2022 - cell.com
Type 2 diabetes mellitus (DM2) is associated closely with non-alcoholic fatty liver disease
(NAFLD) by affecting lipid metabolism, which may lead to non-alcoholic steatohepatitis …

Animal models of nonalcoholic fatty liver disease—a starter's guide

MA Van Herck, L Vonghia, SM Francque - Nutrients, 2017 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) constitutes a major health concern with the
increasing incidence of obesity and diabetes in many Western countries, reaching a …

[PDF][PDF] Mouse models of nonalcoholic steatohepatitis: toward optimization of their relevance to human nonalcoholic steatohepatitis

G Farrell, JM Schattenberg, I Leclercq, MM Yeh… - …, 2019 - Wiley Online Library
Nonalcoholic steatohepatitis (NASH) arises from a variable interplay between environmental
factors and genetic determinants that cannot be completely replicated in animals …

Animal models for liver disease–a practical approach for translational research

YA Nevzorova, Z Boyer-Diaz, FJ Cubero… - Journal of …, 2020 - Elsevier
Animal models are crucial for improving our understanding of human pathogenesis,
enabling researchers to identify therapeutic targets and test novel drugs. In the current …

[HTML][HTML] Preclinical models for studying NASH-driven HCC: how useful are they?

MA Febbraio, S Reibe, S Shalapour, GJ Ooi, MJ Watt… - Cell metabolism, 2019 - cell.com
Hepatocellular carcinoma (HCC) is one of the most fatal and fastest-growing cancers.
Recently, non-alcoholic steatohepatitis (NASH) has been recognized as a major HCC …

[HTML][HTML] Animal models of NAFLD from a hepatologist's point of view

D Jahn, S Kircher, HM Hermanns, A Geier - Biochimica et Biophysica Acta …, 2019 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disorder closely linked to obesity,
hyperlipidemia and type 2 diabetes and is increasingly recognized as a major health …

In vitro and in vivo models of non-alcoholic fatty liver disease: a critical appraisal

PA Soret, J Magusto, C Housset… - Journal of clinical medicine, 2020 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD), including non-alcoholic fatty liver (NAFL) and non-
alcoholic steatohepatitis (NASH), represents the hepatic manifestation of obesity and …

Resolution of NASH and hepatic fibrosis by the GLP-1R and GCGR dual-agonist cotadutide via modulating mitochondrial function and lipogenesis

ML Boland, RC Laker, K Mather, A Nawrocki… - Nature …, 2020 - nature.com
Non-alcoholic fatty liver disease and steatohepatitis are highly associated with obesity and
type 2 diabetes mellitus. Cotadutide, a glucagon-like protein-1 receptor (GLP-1R) and …