Considerable progress has been made in recent years in the structural and molecular
biology of type IV secretion systems in Gram-negative bacteria. The latest advances have …

Helicobacter pylori infections and clinical outcome are dependent on sophisticated
interactions between the bacteria and its host. Crucial bacterial factors associated with …

Summary The Helicobacter pylori (Hp) type IV secretion system (T4SS) forms needle-like
pili, whose binding to the integrin-β 1 receptor results in injection of the CagA oncoprotein …

Three decades have passed since Warren and Marshall described the successful isolation
and culture of Helicobacter pylori, the Gram‐negative bacterium that colonizes the stomach …

Helicobacter pylori colonizes the gastric mucosa in the human stomach and represents a
major risk factor for peptic ulcer disease and gastric cancer. Here, we summarize our current …

Translocation of the Helicobacter pylori (Hp) cytotoxin-associated gene A (CagA) effector
protein via the cag-Type IV Secretion System (cag-T4SS) into host cells is a hallmark of …

Various gram-negative pathogens express type IV secretion systems (T4SSs) which
translocate bacterial virulence factors into host target cells to hijack cellular processes for …

Helicobacter pylori infects half of the world's population, and strains that encode the cag type
IV secretion system for injection of the oncoprotein CagA into host gastric epithelial cells are …

Helicobacter pylori represents an important pathogen involved in diseases ranging from
gastritis, peptic ulceration, to gastric malignancies. Prominent virulence factors comprise the …

Helicobacter pylori is the most predominant bacterium in almost 50% of the world's
population and colonization causes a persistent inflammatory response leading to chronic …