Hypoxia is prevalent in human tumours and contributes to microenvironments that shape
cancer evolution and adversely affect therapeutic outcomes. Historically, two different …

Hypoxia is a state of low oxygen tension found in numerous solid tumours. It is typically
associated with abnormal vasculature, which results in a reduced supply of oxygen and …

The presence of a microenvironment within most tumours containing regions of low oxygen
tension or hypoxia has profound biological and therapeutic implications. Tumour hypoxia is …

Tumour hypoxia has been pursued as a cancer drug target for over 30 years, most notably
using bioreductive (hypoxia-activated) prodrugs that target antineoplastic agents to low …

Hypoxia-activated prodrugs (HAPs) are designed to specifically target the hypoxic cells of
tumors, which are an important cause of treatment resistance to conventional therapies …

Notch signaling is involved in cell fate determination and deregulated in human solid
tumors. Hypoxia is an important feature in many solid tumors, which activates hypoxia …

Hypoxia, as a pervasive feature in the microenvironment of solid tumors, plays a significant
role in cancer progression, metastasis, and ultimately clinical outcome. One key cellular …

Triple-negative breast cancer (TNBC) is one of the deadliest subtypes of breast cancer (BC)
for its high aggressiveness, heterogeneity, and hypoxic nature. Based on biological and …

Quinoxaline 1, 4-di-N-oxides (QdNOs) have manifold biological properties, including
antimicrobial, antitumoral, antitrypanosomal and antiinflammatory/antioxidant activities …

Simple Summary A characteristic across several cancer types is a homologous
recombination deficiency (HRD). HRD is associated with a better response to several …