Prions cause fatal and transmissible neurodegenerative diseases, including Creutzfeldt-
Jakob disease in humans, scrapie in small ruminants, and bovine spongiform …

Sheep are natural hosts of the prion disease, scrapie. They are also susceptible to
experimental challenge with various scrapie strains and with bovine spongiform …

Prion diseases are classically characterized by the accumulation of pathological prion
protein (PrPSc) with the protease resistant C-terminal fragment (PrPres) of 27–30 kDa …

Scrapie in goats has been known since 1942, the archetype of prion diseases in which only
prion protein (PrP) in misfolded state (PrP Sc) acts as infectious agent with fatal …

Thirty-seven goats carrying different prion protein genotypes (PRNP) were orally infected
with a classical scrapie brain homogenate from wild-type (ARQ/ARQ) sheep and then mated …

Classical scrapie is a contagious prion disease of sheep and goats. It is endemic in many
countries in Europe, North America, and Asia. In Africa, imported scrapie cases have been …

Os avanços na biologia molecular têm contribuído significativamente para o entendimento
da etiopatogênese das doenças. Proteínas realizam diferentes funções no organismo e são …

Background. Sheep with prion protein (PrP) gene polymorphisms QQ171 and RQ171 were
shown to be susceptible to the prion causing L-type bovine spongiform encephalopathy (L …

Prions exist as strains, which are thought to reflect PrPSc conformational variants. Prion
strains can mutate and it has been proposed that prion mutability depends on an intrinsic …

Background: Small ruminant lentiviruses (SRLV) belong to genus Lentivirus, family
Retroviridae. These viruses cause caprine arthritis encephalitis (CAE) and maedi visna …