[HTML][HTML] Extracellular vesicle-loaded hydrogels for tissue repair and regeneration

Y Ju, Y Hu, P Yang, X Xie, B Fang - Materials Today Bio, 2023 - Elsevier
Extracellular vesicles (EVs) are a collective term for nanoscale or microscale vesicles
secreted by cells that play important biological roles. Mesenchymal stem cells are a class of …

A paradigm shift in cell-free approach: the emerging role of MSCs-derived exosomes in regenerative medicine

S Moghadasi, M Elveny, HS Rahman… - Journal of translational …, 2021 - Springer
Recently, mesenchymal stem/stromal cells (MSCs) due to their pro-angiogenic, anti-
apoptotic, and immunoregulatory competencies along with fewer ethical issues are …

Biomaterials functionalized with MSC secreted extracellular vesicles and soluble factors for tissue regeneration

MÁ Brennan, P Layrolle… - Advanced functional …, 2020 - Wiley Online Library
The therapeutic benefits of mesenchymal stromal cell (MSC) transplantation are attributed to
their secreted factors, including extracellular vesicles (EVs) and soluble factors. The …

Mechanics of 3D cell–hydrogel interactions: experiments, models, and mechanisms

FJ Vernerey, S Lalitha Sridhar, A Muralidharan… - Chemical …, 2021 - ACS Publications
Hydrogels are highly water-swollen molecular networks that are ideal platforms to create
tissue mimetics owing to their vast and tunable properties. As such, hydrogels are promising …

Development of extracellular vesicle therapeutics: Challenges, considerations, and opportunities

B Claridge, J Lozano, QH Poh… - Frontiers in Cell and …, 2021 - frontiersin.org
Extracellular vesicles (EVs) hold great promise as therapeutic modalities due to their
endogenous characteristics, however, further bioengineering refinement is required to …

Mesenchymal stem cell derived extracellular vesicles for tissue engineering and regenerative medicine applications

D Tsiapalis, L O'Driscoll - Cells, 2020 - mdpi.com
Mesenchymal stem cells (MSCs) are being extensively investigated for their potential in
tissue engineering and regenerative medicine. However, recent evidence suggests that the …

Extracellular vesicles: Emerging frontiers in wound healing

MD Hade, CN Suire, J Mossell… - Medicinal Research …, 2022 - Wiley Online Library
Extracellular vesicles are membranous particles, ranging from 30 nm to 10 µm in diameter,
which are released by nearly all cell types to aid in intercellular communication. These …

Supramolecular nanofibers containing arginine-glycine-aspartate (RGD) peptides boost therapeutic efficacy of extracellular vesicles in kidney repair

C Zhang, Y Shang, X Chen, AC Midgley, Z Wang… - ACS …, 2020 - ACS Publications
Extracellular vesicles (EVs) derived from mesenchymal stem cells (MSC-EVs) have been
recognized as a promising cell-free therapy for acute kidney injury (AKI), which avoids safety …

Extracellular vesicles as biomarkers and therapeutic tools: from pre-clinical to clinical applications

MC Ciferri, R Quarto, R Tasso - Biology, 2021 - mdpi.com
Simple Summary Extracellular vesicles (EVs) are membrane-bound vesicles released by all
cell types, differing in biogenesis, physical characteristics, and contents. Due to their central …

Mesenchymal stem cell–derived exosomes: a promising biological tool in nanomedicine

W Wei, Q Ao, X Wang, Y Cao, Y Liu… - Frontiers in …, 2021 - frontiersin.org
As nano-scale biological vesicles, extracellular vesicles (EVs)/exosomes, in particular,
exosomes derived from mesenchymal stem cells (MSC-exosomes), have been studied in …