Chronic stress, neuroinflammation, and depression: an overview of pathophysiological mechanisms and emerging anti-inflammatories

S Hassamal - Frontiers in psychiatry, 2023 - frontiersin.org
In a subset of patients, chronic exposure to stress is an etiological risk factor for
neuroinflammation and depression. Neuroinflammation affects up to 27% of patients with …

The role of metabolic remodeling in macrophage polarization and its effect on skeletal muscle regeneration

F De Santa, L Vitiello, A Torcinaro… - Antioxidants & redox …, 2019 - liebertpub.com
Significance: Macrophages are crucial for tissue homeostasis. Based on their activation,
they might display classical/M1 or alternative/M2 phenotypes. M1 macrophages produce pro …

[HTML][HTML] ß-Hydroxybutyrate activates the NF-κB signaling pathway to promote the expression of pro-inflammatory factors in calf hepatocytes

X Shi, X Li, D Li, Y Li, Y Song, Q Deng… - Cellular Physiology and …, 2014 - karger.com
Background/Aims: ß-hydroxybutyrate (BHBA) is the major component of ketone bodies in
ketosis. Dairy cows with ketosis often undergo oxidative stress. BHBA is related to the …

How supraphysiological oxygen levels in standard cell culture affect oxygen‐consuming reactions

JA Stuart, J Fonseca, F Moradi… - Oxidative medicine …, 2018 - Wiley Online Library
Most mammalian tissue cells experience oxygen partial pressures in vivo equivalent to 1–
6% O2 (ie, physioxia). In standard cell culture, however, headspace O2 levels are usually …

Inhibition of inducible nitric oxide synthase and cyclooxygenase‐2 in lipopolysaccharide‐stimulated RAW264. 7 cells by carboxybutyrylated glucosamine takes place …

N Rajapakse, MM Kim, E Mendis, SK Kim - Immunology, 2008 - Wiley Online Library
Glucosamine (GlcN) has been reported to possess several biomedical properties, and
currently a great deal of attention has been focused on improving the functional properties of …

Regulation of lymphocytes by nitric oxide

C Bogdan - Suppression and Regulation of Immune Responses …, 2011 - Springer
Shortly after the identification of nitric oxide (NO) as a product of macrophages, it was
discovered that NO generated by inducible NO synthase (iNOS) inhibits the proliferation of T …

Anti-inflammatory effects of methanol extracts of the root of Lilium lancifolium on LPS-stimulated Raw264. 7 cells

OK Kwon, MY Lee, JE Yuk, SR Oh, YW Chin… - Journal of …, 2010 - Elsevier
AIM OF THE STUDY: Lilium lancifolium is commonly used to treat bronchitis, pneumonia,
etc. In this study, we investigated the anti-inflammatory effects of methanol extracts of the …

Regulation of eNOS-derived superoxide by endogenous methylarginines

LJ Druhan, SP Forbes, AJ Pope, CA Chen… - Biochemistry, 2008 - ACS Publications
The endogenous methylarginines, asymmetric dimethylarginine (ADMA) and NG-
monomethyl-l-arginine (L-NMMA) regulate nitric oxide (NO) production from endothelial NO …

Characteristics and function of cardiac mitochondrial nitric oxide synthase

EN Dedkova, LA Blatter - The Journal of physiology, 2009 - Wiley Online Library
We used laser scanning confocal microscopy in combination with the nitric oxide (NO)‐
sensitive fluorescent dye DAF‐2 and the reactive oxygen species (ROS)‐sensitive dyes CM …

7b, a novel naphthalimide derivative, exhibited anti-inflammatory effects via targeted-inhibiting TAK1 following down-regulation of ERK1/2-and p38 MAPK-mediated …

J Shao, Y Li, Z Wang, M Xiao, P Yin, Y Lu… - International …, 2013 - Elsevier
Inflammatory response plays an important role not only in the normal physiology but also in
the pathology such as cancers. 7b, a novel naphthalimide-based DNA intercalator, has …