The role of autophagy in angiotensin II-induced pathological cardiac hypertrophy

L Zhou, B Ma, X Han - Journal of Molecular Endocrinology, 2016 - jme.bioscientifica.com
Pathological cardiac hypertrophy is associated with nearly all forms of heart failure. It
develops in response to disorders such as coronary artery disease, hypertension and …

Role of thyroid hormones-induced oxidative stress on cardiovascular physiology

MLB Arcos - Biochimica et Biophysica Acta (BBA)-General Subjects, 2022 - Elsevier
Thyroid hormones (THs) play an essential role in the maintenance of cardiovascular
homeostasis and are involved in the modulation of cardiac contractility, heart rate, diastolic …

Attenuation of microRNA‐22 derepressed PTEN to effectively protect rat cardiomyocytes from hypertrophy

XD Xu, XW Song, Q Li, GK Wang… - Journal of cellular …, 2012 - Wiley Online Library
Cardiac hypertrophy, which is characterized by the enlargement of cell size, reactivation of
fetal genes, remains one of the most important triggers to heart failure. Increasing evidence …

Sacubitril/valsartan (LCZ696) ameliorates hyperthyroid-induced cardiac hypertrophy in male rats through modulation of miR-377, let-7 b, autophagy, and fibrotic …

T Khamis, AE Alsemeh, DM Abdullah - Scientific Reports, 2022 - nature.com
Hyperthyroidism is associated with cardiac hypertrophy, fibrosis, and increased risk of
cardiovascular mortality. Sacubitril/valsartan (LCZ696) is a new combined drug that has …

Role of oxidative stress in thyroid hormone‐induced cardiomyocyte hypertrophy and associated cardiac dysfunction: an undisclosed story

MT Elnakish, AAE Ahmed, PJ Mohler… - … Medicine and Cellular …, 2015 - Wiley Online Library
Cardiac hypertrophy is the most documented cardiomyopathy following hyperthyroidism in
experimental animals. Thyroid hormone‐induced cardiac hypertrophy is described as a …

Impact of hyperthyroidism on cardiac hypertrophy

MLM Barreto-Chaves, N Senger… - Endocrine …, 2020 - ec.bioscientifica.com
The cardiac growth process (hypertrophy) is a crucial phenomenon conserved across a
wide array of species and is critically involved in the maintenance of cardiac homeostasis …

Thyroid hormones and antioxidant systems: focus on oxidative stress in cardiovascular and pulmonary diseases

A Mancini, S Raimondo, C Di Segni, M Persano… - International Journal of …, 2013 - mdpi.com
In previous works we demonstrated an inverse correlation between plasma Coenzyme Q10
(CoQ10) and thyroid hormones; in fact, CoQ10 levels in hyperthyroid patients were found …

Longstanding hyperthyroidism is associated with normal or enhanced intrinsic cardiomyocyte function despite decline in global cardiac function

NY Weltman, D Wang, RA Redetzke, AM Gerdes - 2012 - journals.plos.org
Thyroid hormones (THs) play a pivotal role in cardiac homeostasis. TH imbalances alter
cardiac performance and ultimately cause cardiac dysfunction. Although short-term …

T3 and T4 decrease ROS levels and increase endothelial nitric oxide synthase expression in the myocardium of infarcted rats

AL de Castro, AV Tavares, RO Fernandes… - Molecular and cellular …, 2015 - Springer
Myocardial infarction leads to a reduction in nitric oxide (NO) bioavailability and an increase
in reactive oxygen species (ROS) levels. This scenario has been shown to be detrimental to …

Angiotensin‐(1‐7) prevents T3‐induced cardiomyocyte hypertrophy by upregulating FOXO3/SOD1/catalase and downregulating NF‐ĸB

N Senger, AC Parletta, BVD Marques… - Journal of Cellular …, 2021 - Wiley Online Library
Clinical studies have shown a correlation between thyroid disorders and cardiac diseases.
High levels of triiodothyronine (T3) induce cardiac hypertrophy, a risk factor for cardiac …