Inflammation is a fundamental protective response that sometimes goes awry and becomes
a major cofactor in the pathogenesis of many chronic human diseases, including cancer …

NF-κB in defense and disease serine residues. Phosphorylated IκBα is then ubiquitinated,
which targets it for degradation by the 26S proteasome (13), thereby releasing NF-κB dimers …

The nuclear factor-κB (NF-κB)/REL family of transcription factors has a central role in
coordinating the expression of a wide variety of genes that control immune responses. There …

Nuclear factor-κB (NF-κB) transcription factors and the signalling pathways that activate
them are central coordinators of innate and adaptive immune responses. More recently, it …

The gram-positive bacterium Listeria monocytogenes is the causative agent of listeriosis, a
highly fatal opportunistic foodborne infection. Pregnant women, neonates, the elderly, and …

The causes of sporadic human cancer are seldom recognized, but it is estimated that
carcinogen exposure and chronic inflammation are two important underlying conditions for …

The choice between life and death is one of the major events in regulation of the immune
system. T cells that specifically recognize viral or bacterial antigens are selected to survive …

NF-κB in defense and disease ing lymphocyte activation (8). The chemotherapeutic agent
etoposide also increases NF-κB levels and thereby induces A1/Bfl-1, which prevents …

IκB kinase/NF-κB (IKK/NF-κB) signaling pathways play critical roles in a variety of
physiological and pathological processes. One function of NF-κB is promotion of cell survival …

The pathophysiology of sepsis and septic shock involves complex cytokine and
inflammatory mediator networks. NF-κB activation is a central event leading to the activation …