LRRK2 and idiopathic Parkinson's disease
The etiology of idiopathic Parkinson's disease (iPD) is multifactorial, and both genetics and
environmental exposures are risk factors. While mutations in leucine-rich repeat kinase-2 …
environmental exposures are risk factors. While mutations in leucine-rich repeat kinase-2 …
Advances in applying computer-aided drug design for neurodegenerative diseases
Neurodegenerative diseases (NDs) including Alzheimer's disease, Parkinson's disease,
amyotrophic lateral sclerosis, and Huntington's disease are incurable and affect millions of …
amyotrophic lateral sclerosis, and Huntington's disease are incurable and affect millions of …
Structure of LRRK2 in Parkinson's disease and model for microtubule interaction
Leucine-rich repeat kinase 2 (LRRK2) is the most commonly mutated gene in familial
Parkinson's disease and is also linked to its idiopathic form. LRRK2 has been proposed to …
Parkinson's disease and is also linked to its idiopathic form. LRRK2 has been proposed to …
Conformational states dynamically populated by a kinase determine its function
INTRODUCTION Protein kinases mediate many cell signaling processes. Central to their
physiological function is the regulation of their binding and enzymatic activities, which is …
physiological function is the regulation of their binding and enzymatic activities, which is …
Structural analysis of the full-length human LRRK2
Mutations in leucine-rich repeat kinase 2 (LRRK2) are commonly implicated in the
pathogenesis of both familial and sporadic Parkinson's disease (PD). LRRK2 regulates …
pathogenesis of both familial and sporadic Parkinson's disease (PD). LRRK2 regulates …
Rab29-dependent asymmetrical activation of leucine-rich repeat kinase 2
Gain-of-function mutations in LRRK2, which encodes the leucine-rich repeat kinase 2
(LRRK2), are the most common genetic cause of late-onset Parkinson's disease. LRRK2 is …
(LRRK2), are the most common genetic cause of late-onset Parkinson's disease. LRRK2 is …
Impact of 100 LRRK2 variants linked to Parkinson's disease on kinase activity and microtubule binding
AF Kalogeropulou, E Purlyte, F Tonelli… - Biochemical …, 2022 - portlandpress.com
Mutations enhancing the kinase activity of leucine-rich repeat kinase-2 (LRRK2) cause
Parkinson's disease (PD) and therapies that reduce LRRK2 kinase activity are being tested …
Parkinson's disease (PD) and therapies that reduce LRRK2 kinase activity are being tested …
Leucine-Rich Repeat Kinases
DR Alessi, SR Pfeffer - Annual Review of Biochemistry, 2024 - annualreviews.org
Activating mutations in leucine-rich repeat kinase 2 (LRRK2) represent the most common
cause of monogenic Parkinson's disease. LRRK2 is a large multidomain protein kinase that …
cause of monogenic Parkinson's disease. LRRK2 is a large multidomain protein kinase that …
[HTML][HTML] Advances in elucidating the function of leucine-rich repeat protein kinase-2 in normal cells and Parkinson's disease
M Taylor, DR Alessi - Current Opinion in Cell Biology, 2020 - Elsevier
Autosomal dominant missense mutations that hyperactivate the leucine-rich repeat protein
kinase-2 (LRRK2) are a common cause of inherited Parkinson's disease and therapeutic …
kinase-2 (LRRK2) are a common cause of inherited Parkinson's disease and therapeutic …
The in situ structure of Parkinson's disease-linked LRRK2
R Watanabe, R Buschauer, J Böhning, M Audagnotto… - Cell, 2020 - cell.com
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most frequent cause of familial
Parkinson's disease. LRRK2 is a multi-domain protein containing a kinase and GTPase …
Parkinson's disease. LRRK2 is a multi-domain protein containing a kinase and GTPase …