Disulfide bridges establish a fundamental element in the molecular architecture of proteins
and peptides which are involved eg, in basic biological processes or acting as toxins. NMR …

Among proteases or proteinases, the endopeptidases account for a significant proportion (∼
2%) of the human genome with over 550 defined members and a further 100 or so predicted …

The non-covalent assembly of proteins that fold separately is central to many biological
processes, and differs from the permanent macromolecular assembly of protein subunits in …

The bloodsucking hemipteran Rhodnius prolixus is a vector of Chagas' disease, which
affects 7–8 million people today in Latin America. In contrast to other hematophagous …

Proteolytic enzymes are potentially hazardous to their protein environment, so that their
activity must be carefully controlled. Living organisms use protein inhibitors as a major tool …

We developed a knowledge-based statistical energy function for protein− ligand, protein−
protein, and protein− DNA complexes by using 19 atom types and ad istance-scale f inite i …

Thrombin is the key enzyme of the entire hemostatic process since it is able to exert both
procoagulant and anticoagulant functions; therefore, it represents an attractive target for the …

Extracting knowledge‐based statistical potential from known structures of proteins is proved
to be a simple, effective method to obtain an approximate free‐energy function. However …

Ornithodorin, isolated from the blood sucking soft tick Ornithodoros moubata, is a potent (Ki=
10 (‐12) M) and highly selective thrombin inhibitor. Internal sequence homology indicates a …

Potent and selective inhibition of the structurally homologous proteases of coagulation
poses challenges for drug development. Hematophagous organisms frequently accomplish …