The increasing extension in life expectancy of human beings in developed countries is
accompanied by a progressively greater rate of degenerative diseases associated with …

Significance: Blood–brain barrier (BBB) disruption is a major pathological change after
intracerebral hemorrhage (ICH) and is both the cause and result of oxidative stress and of …

The transcription factor NF-E2 p45-related factor 2 (Nrf2; gene name NFE2L2) allows
adaptation and survival under conditions of stress by regulating the gene expression of …

Cellular redox homeostasis is precisely balanced by generation and elimination of reactive
oxygen species (ROS). ROS are not only capable of causing oxidation of proteins, lipids and …

The association between chronic inflammation and cancer development has been well
documented. One of the major obstacles in cancer treatment is the persistent autocrine and …

Under physiological conditions, cells are in a stable state known as redox homeostasis,
which is maintained by the balance between continuous ROS/RNS generation and several …

Living cells maintain a balance between oxidation and reduction, and perturbations of this
redox balance are thought to contribute to various diseases. Recent attempts to regulate …

Living organisms are endowed with the capability to tackle various forms of cellular stress
due to the presence of molecular chaperone machinery complexes that are ubiquitous …

Despite the recent successes of targeted cancer immuno-therapies, drug resistance and
disease relapse remain a huge burden in cancer patient treatment. This has fueled renewed …

Alzheimer disease (AD) is a progressive neurodegenerative disorder leading to cognitive
decline, neuropsychiatric symptoms, disability, caregiver burden, and premature death. It …