A goal of human genetics studies is to determine the mechanisms by which genetic variation
produces phenotypic differences that affect human health. Efforts in this respect have …

The cardiovascular system comprises multiple cell types that possess the capacity to
modulate their phenotype in response to acute or chronic injury. Transcriptional and post …

Members of the serine/arginine (SR)‐rich protein family of splicing factors play versatile
roles in RNA processing steps and are often essential for normal development. Dynamic …

RNA splicing brings diversity to the eukaryotic proteome. Different spliced variants of a gene
may differ in their structure, function, localization, and stability influencing protein …

Atherosclerosis is one of the major causes of cerebral infarction and many other ischemic
cardio-cerebrovascular diseases. Although large randomized clinical trials have highlighted …

Circular RNAs (circRNAs) are recognized as a novel type of single-stranded endogenous
noncoding RNA molecule with the characteristics of tissue specificity, sequence …

Emerging evidence has shown that aberrant alternative splicing (AS) events are involved in
the carcinogenesis. The association between genetic variants in AS and bladder cancer …

Abstract Background Oxidized LDL receptor 1 (OLR1) encodes LOX-1, LOXIN, and OLR1D4
transcript variants. Up-regulation of LOX-1 and down-regulation of LOXIN have an essential …

Atherosclerosis is a primary cause of multiple types of cardiovascular disease, including
myocardial infarction. In addition, injury of human umbilical vein endothelial cells (HUVECs) …

Alternative splicing (AS) is a process in which precursor messenger RNA (pre-mRNA)
splicing sites are differentially selected to diversify the protein isoform population. Changes …