Mechanisms of substrate processing during ER-associated protein degradation
JC Christianson, E Jarosch, T Sommer - Nature Reviews Molecular Cell …, 2023 - nature.com
Maintaining proteome integrity is essential for long-term viability of all organisms and is
overseen by intrinsic quality control mechanisms. The secretory pathway of eukaryotes …
overseen by intrinsic quality control mechanisms. The secretory pathway of eukaryotes …
[HTML][HTML] VCP/p97-mediated unfolding as a principle in protein homeostasis and signaling
J van den Boom, H Meyer - Molecular cell, 2018 - cell.com
The AAA+-type ATPase p97 governs an ever-expanding number of cellular processes
reaching from degradation of damaged proteins and organelles to key signaling events and …
reaching from degradation of damaged proteins and organelles to key signaling events and …
Substrate processing by the Cdc48 ATPase complex is initiated by ubiquitin unfolding
INTRODUCTION Many cellular proteins are polyubiquitinated but cannot be directly
degraded by the proteasome because they are well folded, associated with binding …
degraded by the proteasome because they are well folded, associated with binding …
The AAA+ superfamily: a review of the structural and mechanistic principles of these molecular machines
ATPases associated with diverse cellular activities (AAA+ proteins) are a superfamily of
proteins found throughout all domains of life. The hallmark of this family is a conserved …
proteins found throughout all domains of life. The hallmark of this family is a conserved …
Folding and misfolding of human membrane proteins in health and disease: from single molecules to cellular proteostasis
Advances over the past 25 years have revealed much about how the structural properties of
membranes and associated proteins are linked to the thermodynamics and kinetics of …
membranes and associated proteins are linked to the thermodynamics and kinetics of …
2.3 Å resolution cryo-EM structure of human p97 and mechanism of allosteric inhibition
S Banerjee, A Bartesaghi, A Merk, P Rao, SL Bulfer… - Science, 2016 - science.org
p97 is a hexameric AAA+ adenosine triphosphatase (ATPase) that is an attractive target for
cancer drug development. We report cryo–electron microscopy (cryo-EM) structures for …
cancer drug development. We report cryo–electron microscopy (cryo-EM) structures for …
Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death
P Magnaghi, R D'alessio, B Valsasina, N Avanzi… - Nature chemical …, 2013 - nature.com
VCP (also known as p97 or Cdc48p in yeast) is an AAA+ ATPase regulating endoplasmic
reticulum–associated degradation. After high-throughput screening, we developed …
reticulum–associated degradation. After high-throughput screening, we developed …
Structure of the Cdc48 segregase in the act of unfolding an authentic substrate
The cellular machine Cdc48 functions in multiple biological pathways by segregating its
protein substrates from a variety of stable environments such as organelles or multi-subunit …
protein substrates from a variety of stable environments such as organelles or multi-subunit …
[HTML][HTML] A mighty “protein extractor” of the cell: structure and function of the p97/CDC48 ATPase
p97/VCP (known as Cdc48 in S. cerevisiae or TER94 in Drosophila) is one of the most
abundant cytosolic ATPases. It is highly conserved from archaebacteria to eukaryotes. In …
abundant cytosolic ATPases. It is highly conserved from archaebacteria to eukaryotes. In …
Mechanistic insights into the recycling machine of the SNARE complex
Evolutionarily conserved SNARE (soluble N-ethylmaleimide sensitive factor attachment
protein receptors) proteins form a complex that drives membrane fusion in eukaryotes. The …
protein receptors) proteins form a complex that drives membrane fusion in eukaryotes. The …