Molecular networking as a drug discovery, drug metabolism, and precision medicine strategy
Molecular networking is a tandem mass spectrometry (MS/MS) data organizational
approach that has been recently introduced in the drug discovery, metabolomics, and …
approach that has been recently introduced in the drug discovery, metabolomics, and …
The layers of plant responses to insect herbivores
MC Schuman, IT Baldwin - Annual review of entomology, 2016 - annualreviews.org
Plants collectively produce hundreds of thousands of specialized metabolites that are not
required for growth or development. Each species has a qualitatively unique profile, with …
required for growth or development. Each species has a qualitatively unique profile, with …
Propagating annotations of molecular networks using in silico fragmentation
The annotation of small molecules is one of the most challenging and important steps in
untargeted mass spectrometry analysis, as most of our biological interpretations rely on …
untargeted mass spectrometry analysis, as most of our biological interpretations rely on …
Natural history–guided omics reveals plant defensive chemistry against leafhopper pests
Although much is known about plant traits that function in nonhost resistance against
pathogens, little is known about nonhost resistance against herbivores, despite its …
pathogens, little is known about nonhost resistance against herbivores, despite its …
Next-generation mass spectrometry metabolomics revives the functional analysis of plant metabolic diversity
D Li, E Gaquerel - Annual Review of Plant Biology, 2021 - annualreviews.org
The remarkable diversity of specialized metabolites produced by plants has inspired several
decades of research and nucleated a long list of theories to guide empirical ecological …
decades of research and nucleated a long list of theories to guide empirical ecological …
A persistent major mutation in canonical jasmonate signaling is embedded in an herbivory-elicited gene network
R Ray, R Halitschke, K Gase… - Proceedings of the …, 2023 - National Acad Sciences
When insect herbivores attack plants, elicitors from oral secretions and regurgitants (OS)
enter wounds during feeding, eliciting defense responses. These generally require plant …
enter wounds during feeding, eliciting defense responses. These generally require plant …
Current challenges in plant eco-metabolomics
The relatively new research discipline of Eco-Metabolomics is the application of
metabolomics techniques to ecology with the aim to characterise biochemical interactions of …
metabolomics techniques to ecology with the aim to characterise biochemical interactions of …
The genetics of plant metabolism
AR Fernie, T Tohge - Annual Review of Genetics, 2017 - annualreviews.org
Plant metabolic studies have traditionally focused on the role and regulation of the enzymes
catalyzing key reactions within specific pathways. Within the past 20 years, reverse genetic …
catalyzing key reactions within specific pathways. Within the past 20 years, reverse genetic …
Controlled hydroxylations of diterpenoids allow for plant chemical defense without autotoxicity
Many plant specialized metabolites function in herbivore defense, and abrogating particular
steps in their biosynthetic pathways frequently causes autotoxicity. However, the molecular …
steps in their biosynthetic pathways frequently causes autotoxicity. However, the molecular …
[HTML][HTML] How plants synthesize pyrethrins: Safe and biodegradable insecticides
DB Lybrand, H Xu, RL Last, E Pichersky - Trends in plant science, 2020 - cell.com
Natural pyrethrin insecticides produced by Dalmatian pyrethrum (Tanacetum cinerariifolium)
have low mammalian toxicity and short environmental persistence, providing an alternative …
have low mammalian toxicity and short environmental persistence, providing an alternative …