Melatonin: buffering the immune system

A Carrillo-Vico, PJ Lardone… - International journal of …, 2013 - mdpi.com
Melatonin modulates a wide range of physiological functions with pleiotropic effects on the
immune system. Despite the large number of reports implicating melatonin as an …

Utilizing melatonin to combat bacterial infections and septic injury

W Hu, C Deng, Z Ma, D Wang, C Fan… - British journal of …, 2017 - Wiley Online Library
Melatonin, also known as N‐acetyl‐5‐methoxytryptamine, is a ubiquitously acting molecule
that is produced by the pineal gland and other organs of animals, including humans. As …

Role of Melatonin in Bovine Reproductive Biotechnology

Z Li, K Zhang, Y Zhou, J Zhao, J Wang, W Lu - Molecules, 2023 - mdpi.com
Melatonin has profound antioxidant activity and numerous functions in humans as well as in
livestock and poultry. Additionally, melatonin plays an important role in regulating the …

Melatonin protects CD4+ T cells from activation-induced cell death by blocking NFAT-mediated CD95 ligand upregulation

AMC Pedrosa, R Weinlich, GP Mognol… - The Journal of …, 2010 - journals.aai.org
Over the past 20 y, the hormone melatonin was found to be produced in extrapineal sites,
including cells of the immune system. Despite the increasing data regarding the biological …

Melatonin as immune potentiator for enhancing subunit vaccine efficacy against bovine viral diarrhea virus

YX Wang, GH Yang, LL Zhang, J Wang, JF Wang - Vaccines, 2021 - mdpi.com
Bovine viral diarrhea virus (BVDV) is a pathogen associated with substantial economic
losses in the dairy cattle industry. Currently, there are no effective vaccines against BVDV …

Potential relevance of melatonin against some infectious agents: a review and assessment of recent research

E Kotb Elmahallawy, J Ortega Luque… - Current medicinal …, 2015 - ingentaconnect.com
Melatonin, a tryptophan-derived neurohormone found in animals, plants, and microbes,
participates in various biological and physiological functions. Among other properties …

Nano-Encapsulated Melatonin: A Promising Mucosal Adjuvant in Intranasal Immunization against Chronic Experimental T. gondii Infection

DE Said, EI Amer, E Sheta, S Makled, HE Diab… - Tropical Medicine and …, 2022 - mdpi.com
Melatonin (MLT) is now emerging as one of the universally accepted immunostimulators
with broad applications in medicine. It is a biological manipulator of the immune system …

Melatonin enhances responsiveness to Dichelobacter nodosus vaccine in sheep and increases peripheral blood CD4 T lymphocytes and IgG-expressing B …

A Ramos, MP Míguez, S Morgado… - Veterinary immunology …, 2018 - Elsevier
The immunomodulatory functions mediated by melatonin support its use as vaccine
adjuvant. Previously, we have demonstrated that melatonin enhances antibody responses in …

Immunoregulatory Properties of Melatonin in the Humoral Immune System: A Narrative Review

JR Calvo, MD Maldonado - Immunology Letters, 2024 - Elsevier
Melatonin is the major product both synthesized and secreted by the pineal gland during the
night period and it is the principal chronobiotic hormone that regulates the circadian rhythms …

Melatonin in animal husbandry: functions and applications

R Zhao, Y Bai, F Yang - Frontiers in Veterinary Science, 2024 - frontiersin.org
Melatonin (N-acetyl-5-methoxytryptamine) is an essential small molecule with diverse
biological functions. It plays several key roles, including regulating the secretion of …