Tuberculosis: an overview of the immunogenic response, disease progression, and medicinal chemistry efforts in the last decade toward the development of potential …

A Sharma, M De Rosa, N Singla, G Singh… - Journal of medicinal …, 2021 - ACS Publications
Tuberculosis (TB) is a slow growing, potentially debilitating disease that has plagued
humanity for centuries and has claimed numerous lives across the globe. Concerted efforts …

Phylogeography and transmission of M. tuberculosis in Moldova: A prospective genomic analysis

C Yang, B Sobkowiak, V Naidu, A Codreanu… - PLoS …, 2022 - journals.plos.org
Background The incidence of multidrug-resistant tuberculosis (MDR-TB) remains critically
high in countries of the former Soviet Union, where> 20% of new cases and> 50% of …

Association between HIV and acquisition of rifamycin resistance with first-line TB treatment: a systematic review and meta-analysis

N Zinyakatira, N Ford, H Cox - BMC Infectious Diseases, 2024 - Springer
Background Multi-drug or rifamycin-resistant tuberculosis (MDR/RR-TB) is an important
public health concern, including in settings with high HIV prevalence. TB drug resistance …

High rates of multidrug-resistant and rifampicin-resistant tuberculosis among re-treatment cases: where do they come from?

R Ragonnet, JM Trauer, JT Denholm, BJ Marais… - BMC infectious …, 2017 - Springer
Abstract Background Globally 3.9% of new and 21% of re-treatment tuberculosis (TB) cases
are multidrug-resistant or rifampicin-resistant (MDR/RR), which is often interpreted as …

Knowledge and practice of health workers about control and prevention of multidrug-resistant tuberculosis in referral hospitals, Ethiopia: a cross-sectional study

KA Alene, AA Adane, S Yifiru, BD Bitew, A Adane… - BMJ open, 2019 - bmjopen.bmj.com
Objective The aim of this study was to assess the knowledge and practice of health workers
about multidrug-resistant tuberculosis (MDR-TB) prevention and control. Study design and …

The recent rapid expansion of multidrug resistant Ural lineage Mycobacterium tuberculosis in Moldova

MH Chitwood, C Colijn, C Yang, V Crudu… - Nature …, 2024 - nature.com
The projected trajectory of multidrug resistant tuberculosis (MDR-TB) epidemics depends on
the reproductive fitness of circulating strains of MDR M. tuberculosis (Mtb). Previous efforts to …

A retrospective genomic analysis of drug-resistant strains of M. tuberculosis in a high-burden setting, with an emphasis on comparative diagnostics and reactivation …

K Wollenberg, M Harris, A Gabrielian, N Ciobanu… - BMC infectious …, 2020 - Springer
Background Recurrence of drug-resistant tuberculosis (DR-TB) after treatment occurs
through relapse of the initial infection or reinfection by a new drug-resistant strain. Outbreaks …

Evolution and emergence of multidrug-resistant Mycobacterium tuberculosis in Chisinau, Moldova

TS Brown, V Eldholm, O Brynildsrud… - Microbial …, 2021 - microbiologyresearch.org
The evolution and emergence of drug-resistant tuberculosis (TB) has been studied
extensively in some contexts, but the ecological drivers of these two processes remain …

Clinical management of multidrug-resistant tuberculosis in 16 European countries

G Günther, F van Leth, S Alexandru, N Altet… - American journal of …, 2018 - atsjournals.org
Rationale: Multidrug-resistant tuberculosis (MDR-TB) is a major burden to public health in
Europe. Reported treatment success rates are around 50% or less, and cure rates are even …

The recent rapid expansion of multidrug resistant strains of Mycobacterium tuberculosis Ural lineage 4.2 in the Republic of Moldova

MH Chitwood, C Colijn, C Yang, V Crudu, N Ciobanu… - medRxiv, 2023 - medrxiv.org
The projected trajectory of multidrug resistant tuberculosis (MDR-TB) epidemics depends on
the reproductive fitness of circulating strains of MDR M. tuberculosis (Mtb). Previous efforts to …