Anxiety is the most common mental health problem worldwide. Epidemiological studies
show that sleep disturbances, particularly insomnia, affect∼ 50% of individuals with anxiety …

The gabapentinoids, gabapentin, and pregabalin, target the α2δ subunits of voltage-gated
calcium channels. Initially licensed for pain and seizures, they have become widely …

Solute carriers (SLCs) are the largest family of transmembrane transporters that determine
the exchange of various substances, including nutrients, ions, metabolites, and drugs across …

Background: Gabapentin (GBP)-induced movement disorders (MDs) are under-recognized
adverse drug reactions. They are commonly not discussed with patients, and their sudden …

Objective: Although gabapentin has demonstrated efficacy in mitigating alcohol withdrawal
symptoms and preventing relapse drinking in individuals with alcohol use disorder (AUD) …

Adult brain structures such as the hippocampus are highly plastic to learning and gaining
new experiences. Recent studies reveal that cortical areas that respond to sensory noxious …

Central post-stroke pain (CPSP) is a severe chronic neuropathic pain syndrome that is a
direct result of cerebrovascular lesions affecting the central somatosensory system. The …

Dysregulated GABAergic inhibition in the amygdala has long been implicated in stress-
related neuropsychiatric disorders. However, the molecular and circuit mechanisms …

During the last 100 years, the role of anesthesiologists in psychiatry has focused primarily
on facilitating electroconvulsive therapy and mitigating postoperative delirium and other …

Undoubtedly, opioid drugs have been the most popular treatment for refractory pain since
found, such as morphine. However, tolerance to the analgesic effects caused by repeated …