Major insights into the phylogenetic distribution, biochemistry, and evolutionary significance
of organelles involved in ATP synthesis (energy metabolism) in eukaryotes that thrive in …

The eukaryotic intestinal parasite Giardia intestinalis was first described in 1681, when
Antonie van Leeuwenhoek undertook a microscopic examination of his own diarrhoeal …

Eukaryogenesis, the origin of the eukaryotic cell, represents one of the fundamental
evolutionary transitions in the history of life on earth. This event, which is estimated to have …

Background The transition from prokaryotes to eukaryotes was the most radical change in
cell organisation since life began, with the largest ever burst of gene duplication and novelty …

The mitochondria have arisen as a consequence of endosymbiosis of an ancestral α-
proteobacterium with a methane-producing archae. The main function of the canonical …

All extant eukaryotes are now considered to possess mitochondria in one form or another.
Many parasites or anaerobic protists have highly reduced versions of mitochondria, which …

The mitosomes of Giardia intestinalis are thought to be mitochondria highly-reduced in
response to the oxygen-poor niche. We performed a quantitative proteomic assessment of …

Hydrogenosomes and mitosomes are mitochondrion-related organelles in anaerobic/
microaerophilic eukaryotes with highly reduced and divergent functions. The full diversity of …

Mitochondrial metabolism is entirely dependent on the biosynthesis of the [4Fe-4S] clusters,
which are part of the subunits of the respiratory chain. The mitochondrial late ISC pathway …

Proteins residing in the mitochondrial outer membrane facilitate various interactions
between the organelle and the rest of the eukaryotic cell. All these proteins are encoded in …