CRISPR in cancer biology and therapy

A Katti, BJ Diaz, CM Caragine, NE Sanjana… - Nature Reviews …, 2022 - nature.com
Over the past decade, CRISPR has become as much a verb as it is an acronym,
transforming biomedical research and providing entirely new approaches for dissecting all …

Off-target effects in CRISPR/Cas9 gene editing

C Guo, X Ma, F Gao, Y Guo - Frontiers in bioengineering and …, 2023 - frontiersin.org
Gene editing stands for the methods to precisely make changes to a specific nucleic acid
sequence. With the recent development of the clustered regularly interspaced short …

Human genetic diversity alters off-target outcomes of therapeutic gene editing

S Cancellieri, J Zeng, LY Lin, M Tognon, MA Nguyen… - Nature …, 2023 - nature.com
CRISPR gene editing holds great promise to modify DNA sequences in somatic cells to treat
disease. However, standard computational and biochemical methods to predict off-target …

Latest developed strategies to minimize the off-target effects in CRISPR-Cas-mediated genome editing

M Naeem, S Majeed, MZ Hoque, I Ahmad - Cells, 2020 - mdpi.com
Gene editing that makes target gene modification in the genome by deletion or addition has
revolutionized the era of biomedicine. Clustered regularly interspaced short palindromic …

Explainable machine learning for scientific insights and discoveries

R Roscher, B Bohn, MF Duarte, J Garcke - Ieee Access, 2020 - ieeexplore.ieee.org
Machine learning methods have been remarkably successful for a wide range of application
areas in the extraction of essential information from data. An exciting and relatively recent …

Artificial intelligence and machine learning in precision and genomic medicine

S Quazi - Medical Oncology, 2022 - Springer
The advancement of precision medicine in medical care has led behind the conventional
symptom-driven treatment process by allowing early risk prediction of disease through …

High-performance medicine: the convergence of human and artificial intelligence

EJ Topol - Nature medicine, 2019 - nature.com
The use of artificial intelligence, and the deep-learning subtype in particular, has been
enabled by the use of labeled big data, along with markedly enhanced computing power …

New insights into the degradation of synthetic pollutants in contaminated environments

P Bhatt, S Gangola, G Bhandari, W Zhang, D Maithani… - Chemosphere, 2021 - Elsevier
The environment is contaminated by synthetic contaminants owing to their extensive
applications globally. Hence, the removal of synthetic pollutants (SPs) from the environment …

Machine learning for metabolic engineering: A review

CE Lawson, JM Martí, T Radivojevic… - Metabolic …, 2021 - Elsevier
Abstract Machine learning provides researchers a unique opportunity to make metabolic
engineering more predictable. In this review, we offer an introduction to this discipline in …

Machine learning meets omics: applications and perspectives

R Li, L Li, Y Xu, J Yang - Briefings in Bioinformatics, 2022 - academic.oup.com
The innovation of biotechnologies has allowed the accumulation of omics data at an
alarming rate, thus introducing the era of 'big data'. Extracting inherent valuable knowledge …