CRISPR in cancer biology and therapy
Over the past decade, CRISPR has become as much a verb as it is an acronym,
transforming biomedical research and providing entirely new approaches for dissecting all …
transforming biomedical research and providing entirely new approaches for dissecting all …
Off-target effects in CRISPR/Cas9 gene editing
C Guo, X Ma, F Gao, Y Guo - Frontiers in bioengineering and …, 2023 - frontiersin.org
Gene editing stands for the methods to precisely make changes to a specific nucleic acid
sequence. With the recent development of the clustered regularly interspaced short …
sequence. With the recent development of the clustered regularly interspaced short …
Human genetic diversity alters off-target outcomes of therapeutic gene editing
CRISPR gene editing holds great promise to modify DNA sequences in somatic cells to treat
disease. However, standard computational and biochemical methods to predict off-target …
disease. However, standard computational and biochemical methods to predict off-target …
Latest developed strategies to minimize the off-target effects in CRISPR-Cas-mediated genome editing
Gene editing that makes target gene modification in the genome by deletion or addition has
revolutionized the era of biomedicine. Clustered regularly interspaced short palindromic …
revolutionized the era of biomedicine. Clustered regularly interspaced short palindromic …
Explainable machine learning for scientific insights and discoveries
Machine learning methods have been remarkably successful for a wide range of application
areas in the extraction of essential information from data. An exciting and relatively recent …
areas in the extraction of essential information from data. An exciting and relatively recent …
Artificial intelligence and machine learning in precision and genomic medicine
S Quazi - Medical Oncology, 2022 - Springer
The advancement of precision medicine in medical care has led behind the conventional
symptom-driven treatment process by allowing early risk prediction of disease through …
symptom-driven treatment process by allowing early risk prediction of disease through …
High-performance medicine: the convergence of human and artificial intelligence
EJ Topol - Nature medicine, 2019 - nature.com
The use of artificial intelligence, and the deep-learning subtype in particular, has been
enabled by the use of labeled big data, along with markedly enhanced computing power …
enabled by the use of labeled big data, along with markedly enhanced computing power …
New insights into the degradation of synthetic pollutants in contaminated environments
The environment is contaminated by synthetic contaminants owing to their extensive
applications globally. Hence, the removal of synthetic pollutants (SPs) from the environment …
applications globally. Hence, the removal of synthetic pollutants (SPs) from the environment …
Machine learning for metabolic engineering: A review
Abstract Machine learning provides researchers a unique opportunity to make metabolic
engineering more predictable. In this review, we offer an introduction to this discipline in …
engineering more predictable. In this review, we offer an introduction to this discipline in …
Machine learning meets omics: applications and perspectives
The innovation of biotechnologies has allowed the accumulation of omics data at an
alarming rate, thus introducing the era of 'big data'. Extracting inherent valuable knowledge …
alarming rate, thus introducing the era of 'big data'. Extracting inherent valuable knowledge …