Adiponectin signaling and function in insulin target tissues
Obesity-linked type 2 diabetes is one of the paramount causes of morbidity and mortality
worldwide, posing a major threat on human health, productivity, and quality of life. Despite …
worldwide, posing a major threat on human health, productivity, and quality of life. Despite …
Adiponectin regulation and function
H Fang, RL Judd - Comprehensive Physiology, 2011 - Wiley Online Library
Adipose tissue is now recognized as an important endocrine organ, capable of secreting a
large number of endocrine factors which regulate a wide variety of physiological functions …
large number of endocrine factors which regulate a wide variety of physiological functions …
DsbA-L prevents obesity-induced inflammation and insulin resistance by suppressing the mtDNA release-activated cGAS-cGAMP-STING pathway
Chronic inflammation in adipose tissue plays a key role in obesity-induced insulin
resistance. However, the mechanisms underlying obesity-induced inflammation remain …
resistance. However, the mechanisms underlying obesity-induced inflammation remain …
[HTML][HTML] DsbA-L mediated renal tubulointerstitial fibrosis in UUO mice
Recent studies have reported that upregulation of disulfide-bond A oxidoreductase-like
protein (DsbA-L) prevented lipid-induced renal injury in diabetic nephropathy (DN) …
protein (DsbA-L) prevented lipid-induced renal injury in diabetic nephropathy (DN) …
'Metabolically healthy obesity': origins and implications
GV Denis, MS Obin - Molecular aspects of medicine, 2013 - Elsevier
When humans eat more and exercise less, they tend to become obese and unhealthy. The
molecular pathways that link obesity to serious diseases like Type 2 diabetes and …
molecular pathways that link obesity to serious diseases like Type 2 diabetes and …
Adiponectin supplementation in pregnant mice prevents the adverse effects of maternal obesity on placental function and fetal growth
Mothers with obesity or gestational diabetes mellitus have low circulating levels of
adiponectin (ADN) and frequently deliver large babies with increased fat mass, who are …
adiponectin (ADN) and frequently deliver large babies with increased fat mass, who are …
[HTML][HTML] The cGAS–STING pathway: more than fighting against viruses and cancer
T Bao, J Liu, J Leng, L Cai - Cell & Bioscience, 2021 - Springer
In the classic Cyclic guanosine monophosphate–adenosine monophosphate (cGAMP)
synthase (cGAS)-stimulator of interferon genes (STING) pathway, downstream signals can …
synthase (cGAS)-stimulator of interferon genes (STING) pathway, downstream signals can …
[HTML][HTML] Mitochondrial stress-activated cGAS-STING pathway inhibits thermogenic program and contributes to overnutrition-induced obesity in mice
Obesity is a global epidemic that is caused by excessive energy intake or inefficient energy
expenditure. Brown or beige fat dissipates energy as heat through non-shivering …
expenditure. Brown or beige fat dissipates energy as heat through non-shivering …
Regulation of adiponectin multimerization, signaling and function
Adiponectin, which exists in serum in three major complexes including trimer, hexamer, and
the high molecular weight (HMW) form, has strong insulin sensitizing, anti-inflammatory and …
the high molecular weight (HMW) form, has strong insulin sensitizing, anti-inflammatory and …
Adiponectin as a potential biomarker of vascular disease
M Ebrahimi-Mamaeghani, S Mohammadi… - Vascular health and …, 2015 - Taylor & Francis
The increasing prevalence of diabetes and its complications heralds an alarming situation
worldwide. Obesity-associated changes in circulating adiponectin concentrations have the …
worldwide. Obesity-associated changes in circulating adiponectin concentrations have the …