Many proteins first identified in the immune system are also expressed in the developing
and adult nervous system. Unexpectedly, recent studies reveal that a number of these …

Although the brain has classically been considered “immune-privileged”, current research
suggests an extensive communication between the immune and nervous systems in both …

The ubiquitin-proteasome system (UPS) is the major intracellular proteolytic mechanism
controlling the degradation of misfolded/abnormal proteins. A common hallmark in …

We here review the loss of muscle function and mass (sarcopenia) in the framework of
human healthspan and lifespan, and mechanisms involved in aging. The rapidly changing …

Motor disturbances and wasting of skeletal muscles (sarcopenia) causes significant
impairment of daily life activities and is a major underlying cause for hospitalization in …

Neuronal expression of major histocompatibility complex I (MHC-I) has been implicated in
developmental synaptic plasticity and axonal regeneration in the central nervous system …

Proteins of the major histocompatibility complex class I (MHCI) are known for their role in
immunity and have recently been implicated in long-term plasticity of excitatory synaptic …

Nonimmune mechanisms contribute to the pathogenesis of IIM, likely cooperating with
immune-mediated inflammation. Consistent data were released for ER stress, autophagy …

Proteins of the major histocompatibility complex class I (MHCI) negatively regulate synapse
density in the developing vertebrate brain (;;), but the underlying mechanisms remain largely …

Background Chronic obstructive pulmonary disease (COPD) is a common respiratory
disease, whose pathogenetic complexity was strongly associated with aging/smoking and …