Neuroinflammation and oxidative stress in the pathogenesis of autism spectrum disorder
N Usui, H Kobayashi, S Shimada - International Journal of Molecular …, 2023 - mdpi.com
Autism spectrum disorder (ASD) is a neurodevelopmental disorder (NDD) characterized by
impairments in social communication, repetitive behaviors, restricted interests, and …
impairments in social communication, repetitive behaviors, restricted interests, and …
The inflamed brain in schizophrenia: the convergence of genetic and environmental risk factors that lead to uncontrolled neuroinflammation
Schizophrenia is a disorder with a heterogeneous etiology involving complex interplay
between genetic and environmental risk factors. The immune system is now known to play …
between genetic and environmental risk factors. The immune system is now known to play …
Maternal immune activation induces autism-like changes in behavior, neuroinflammatory profile and gut microbiota in mouse offspring of both sexes
AM Tartaglione, A Villani, MA Ajmone-Cat… - Translational …, 2022 - nature.com
Abstract Autism Spectrum Disorder (ASD) is a sex-biased neurodevelopmental disorder with
a male to female prevalence of 4: 1, characterized by persistent deficits in social …
a male to female prevalence of 4: 1, characterized by persistent deficits in social …
Maternal and early postnatal immune activation produce sex-specific effects on autism-like behaviors and neuroimmune function in mice
Increasing evidence suggests a role for inflammation in neuropsychiatric conditions
including autism spectrum disorder (ASD), a neurodevelopmental syndrome with higher …
including autism spectrum disorder (ASD), a neurodevelopmental syndrome with higher …
LPS versus Poly I: C model: comparison of long-term effects of bacterial and viral maternal immune activation on the offspring
M Bao, N Hofsink, T Plösch - American Journal of …, 2022 - journals.physiology.org
A prominent health issue nowadays is the COVID-19 pandemic, which poses acute risks to
human health. However, the long-term health consequences are largely unknown and …
human health. However, the long-term health consequences are largely unknown and …
Sex-specific neurodevelopmental outcomes among offspring of mothers with SARS-CoV-2 infection during pregnancy
Importance Prior studies using large registries have suggested a modest increase in risk for
neurodevelopmental diagnoses among children of mothers with immune activation during …
neurodevelopmental diagnoses among children of mothers with immune activation during …
Sex differences in offspring risk and resilience following 11β-hydroxylase antagonism in a rodent model of maternal immune activation
J Martz, MA Shelton, L Geist, ML Seney… - …, 2024 - nature.com
Maternal immune activation (MIA) puts offspring at greater risk for neurodevelopmental
disorders associated with impaired social behavior. While it is known that immune signaling …
disorders associated with impaired social behavior. While it is known that immune signaling …
A comprehensive approach to modeling maternal immune activation in rodents
MC Bucknor, A Gururajan, RC Dale… - Frontiers in …, 2022 - frontiersin.org
Prenatal brain development is a highly orchestrated process, making it a very vulnerable
window to perturbations. Maternal stress and subsequent inflammation during pregnancy …
window to perturbations. Maternal stress and subsequent inflammation during pregnancy …
Cerebellar and striatal implications in autism spectrum disorders: from clinical observations to animal models
M Thabault, V Turpin, A Maisterrena, M Jaber… - International Journal of …, 2022 - mdpi.com
Autism spectrum disorders (ASD) are complex conditions that stem from a combination of
genetic, epigenetic and environmental influences during early pre-and postnatal childhood …
genetic, epigenetic and environmental influences during early pre-and postnatal childhood …
Increased glutamate and glutamine levels and their relationship to astrocytes and dopaminergic transmissions in the brains of adults with autism
Increased excitatory neuronal tones have been implicated in autism, but its mechanism
remains elusive. The amplified glutamate signals may arise from enhanced glutamatergic …
remains elusive. The amplified glutamate signals may arise from enhanced glutamatergic …