Mutations in RNA binding motif protein 20 (RBM20) are a common cause of familial dilated
cardiomyopathy (DCM). Many RBM20 mutations cluster within an arginine/serine-rich (RS …

Severe forms of dilated cardiomyopathy (DCM) are associated with point mutations in the
alternative splicing regulator RBM20 that are frequently located in the arginine/serine-rich …

Cardiac development and function are becoming increasingly well understood from different
angles, including signalling, transcriptional and epigenetic mechanisms. By contrast, the …

RBM20 (RNA-binding motif protein 20) is a vertebrate-and muscle-specific RNA-binding
protein that belongs to the serine-arginine-rich family of splicing factors. The RBM20 gene …

Dilated cardiomyopathy is the second most common cause for heart failure with no cure
except a high-risk heart transplantation. Approximately 30% of patients harbor heritable …

Sorafenib, a multi-targeted tyrosine kinase inhibitor, is a first-line treatment for advanced
solid tumors, but it induces many adverse cardiovascular events, including myocardial …

Considering the worldwide impact of heart failure, it is crucial to develop approaches that
can help us comprehend its root cause and make accurate predictions about its outcome …

Human patients carrying genetic mutations in RNA binding motif 20 (RBM20) develop a
clinically aggressive dilated cardiomyopathy (DCM). Genetic mutation knockin (KI) animal …

RBM20 cardiomyopathy is an arrhythmogenic form of dilated cardiomyopathy caused by
mutations in the splicing factor RBM20. A recent study found a more severe phenotype in …

Most splicing factors are extensively phosphorylated but their physiological functions in plant
salt resistance are still elusive. We found that phosphorylation by SnRK1 kinase is essential …