Vascular endothelial growth factor signaling in hypoxia and inflammation
Infection, cancer and cardiovascular diseases are the major causes for morbidity and
mortality in the United States according to the Center for Disease Control. The underlying …
mortality in the United States according to the Center for Disease Control. The underlying …
Role of prenatal hypoxia in brain development, cognitive functions, and neurodegeneration
NN Nalivaeva, AJ Turner, IA Zhuravin - Frontiers in neuroscience, 2018 - frontiersin.org
This review focuses on the role of prenatal hypoxia in the development of brain functions in
the postnatal period and subsequent increased risk of neurodegenerative disorders in later …
the postnatal period and subsequent increased risk of neurodegenerative disorders in later …
Integrated proteogenomic characterization across major histological types of pediatric brain cancer
We report a comprehensive proteogenomics analysis, including whole-genome sequencing,
RNA sequencing, and proteomics and phosphoproteomics profiling, of 218 tumors across 7 …
RNA sequencing, and proteomics and phosphoproteomics profiling, of 218 tumors across 7 …
Multi-omics analysis defines core genomic alterations in pheochromocytomas and paragangliomas
Abstract Pheochromocytomas and paragangliomas (PCCs/PGLs) are neural crest-derived
tumours with a very strong genetic component. Here we report the first integrated genomic …
tumours with a very strong genetic component. Here we report the first integrated genomic …
Brain microRNAs and insights into biological functions and therapeutic potential of brain enriched miRNA-128
YK Adlakha, N Saini - Molecular cancer, 2014 - Springer
MicroRNAs, the non-coding single-stranded RNA of 19–25 nucleotides are emerging as
robust players of gene regulation. Plethora of evidences support that the ability of …
robust players of gene regulation. Plethora of evidences support that the ability of …
The microRNA-183 cluster: the family that plays together stays together
S Dambal, M Shah, B Mihelich, L Nonn - Nucleic acids research, 2015 - academic.oup.com
Abstract The microRNA (miR) 183 cluster, which is comprised of miRs-183,-96 and-182, is
also a miR family with sequence homology. Despite the strong similarity in the sequences of …
also a miR family with sequence homology. Despite the strong similarity in the sequences of …
[HTML][HTML] Micromanaging aerobic respiration and glycolysis in cancer cells
Background Cancer cells possess a common metabolic phenotype, rewiring their metabolic
pathways from mitochondrial oxidative phosphorylation to aerobic glycolysis and anabolic …
pathways from mitochondrial oxidative phosphorylation to aerobic glycolysis and anabolic …
Hypoxic signature of microRNAs in glioblastoma: insights from small RNA deep sequencing
Background Hypoxia is a critical aspect of the glioma microenvironment and has been
associated with poor prognosis and resistance to various therapies. However, the …
associated with poor prognosis and resistance to various therapies. However, the …
Decoding the regulatory roles of non-coding RNAs in cellular metabolism and disease
Y Zong, X Wang, B Cui, X Xiong, A Wu, C Lin, Y Zhang - Molecular Therapy, 2023 - cell.com
Non-coding RNAs, including long non-coding RNAs (lncRNAs), microRNAs (miRNAs), and
circular RNAs (circRNAs), are being studied extensively in a variety of fields. Their roles in …
circular RNAs (circRNAs), are being studied extensively in a variety of fields. Their roles in …
The tumour hypoxia induced non-coding transcriptome
H Choudhry, AL Harris, A McIntyre - Molecular aspects of medicine, 2016 - Elsevier
Recent investigations have highlighted the importance of the non-coding genome in regions
of hypoxia in tumours. Such regions are frequently found in solid tumours, and are …
of hypoxia in tumours. Such regions are frequently found in solid tumours, and are …