Adverse effects of synthetic cannabinoids: management of acute toxicity and withdrawal

ZD Cooper - Current psychiatry reports, 2016 - Springer
Although several chemical structural classes of synthetic cannabinoids (SCs) were recently
classified as Schedule I substances, rates of use and cases of serious toxic effects remain …

Synthetic cathinone and cannabinoid designer drugs pose a major risk for public health

AM Weinstein, P Rosca, L Fattore… - Frontiers in psychiatry, 2017 - frontiersin.org
As part of an increasing worldwide use of designer drugs, recent use of compounds
containing cathinones and synthetic cannabinoids is especially prevalent. Here, we …

Reports of adverse events associated with use of novel psychoactive substances, 2013–2016: a review

BK Logan, ALA Mohr, M Friscia… - Journal of Analytical …, 2017 - academic.oup.com
Novel psychoactive substances (NPS) represent significant analytical and interpretive
challenges to forensic and clinical toxicologists. Timely access to case reports and reports of …

Synthetic cannabinoids—further evidence supporting the relationship between cannabinoids and psychosis

L Fattore - Biological psychiatry, 2016 - Elsevier
Consumption of synthetic mind-altering compounds, also known as “new psychoactive
substances,” is increasing globally at an alarming rate. Synthetic cannabinoids (SCs) are …

The newest cathinone derivatives as designer drugs: an analytical and toxicological review

M Majchrzak, R Celiński, P Kuś, T Kowalska… - Forensic toxicology, 2018 - Springer
Purpose Currently, among new psychoactive substances, cathinone derivatives constitute
the biggest group, which are mainly classified into N-alkylated, 3, 4-methylenedioxy-N …

Cannabinoids exacerbate alcohol teratogenesis by a CB1-hedgehog interaction

EW Fish, LB Murdaugh, C Zhang, KE Boschen… - Scientific reports, 2019 - nature.com
We tested whether cannabinoids (CBs) potentiate alcohol-induced birth defects in mice and
zebrafish, and explored the underlying pathogenic mechanisms on Sonic Hedgehog (Shh) …

Abuse potential and toxicity of the synthetic cathinones (ie,“Bath salts”)

AL Riley, KH Nelson, P To, R López-Arnau, P Xu… - Neuroscience & …, 2020 - Elsevier
The synthetic cathinones are derived from the naturally occurring drug cathinone found in
the khat plant (Catha edulis) and have chemical structures and neurochemical …

Neuropharmacology of synthetic cathinones

MH Baumann, HM Walters, M Niello… - … , Clinical, Forensic and …, 2018 - Springer
Synthetic cathinones are derivatives of the naturally occurring compound cathinone, the
main psychoactive ingredient in the khat plant Catha edulis. Cathinone is the β-keto analog …

A deep generative model enables automated structure elucidation of novel psychoactive substances

MA Skinnider, F Wang, D Pasin, R Greiner… - Nature Machine …, 2021 - nature.com
Over the past decade, the illicit drug market has been reshaped by the proliferation of
clandestinely produced designer drugs. These agents, referred to as new psychoactive …

Cannabis use, abuse, and withdrawal: Cannabinergic mechanisms, clinical, and preclinical findings

AJ Kesner, DM Lovinger - Journal of neurochemistry, 2021 - Wiley Online Library
Cannabis sativa is the most widely used illicit drug in the world. Its main psychoactive
component is delta‐9‐tetrahydrocannabinol (THC), one of over 100 phytocannabinoid …