Circadian rhythms are internal manifestations of the solar day that permit adaptations to
predictable environmental temporal changes. These~ 24-h rhythms are controlled by …

Despite a complex relationship between mood, sleep and rhythm, the impact of circadian
disruptions on bipolar disorder (BD) has not been clarified. The purpose of this systematic …

Sleep disturbances and circadian rhythm dysfunction have been widely demonstrated in
patients with bipolar disorder (BD). Irregularity of the sleep–wake rhythm, eveningness …

Circadian rhythm disturbances are a common symptom among individuals with mood
disorders. The suprachiasmatic nucleus (SCN), in the ventral part of the anterior …

Abstract Purpose of Review We review recent evidence for circadian rhythm dysregulation in
bipolar spectrum disorders (BSDs). We examine evidence for endogenous abnormalities in …

Major mood syndromes are among the most common and disabling mental disorders.
However, a lack of clear delineation of their underlying pathophysiological mechanisms is a …

Depressive syndromes are frequent and heterogeneous brain conditions with more than
90% of patients suffering from sleep complaints. Better characterizing this “sleep” domain …

Bipolar disorder (BD) is a chronic and progressive psychiatric illness characterized by mood
oscillations, with episodes of mania and depression. The impact of BD on patients can be …

Objectives The aims of the present study were to confirm the impact of residual symptoms on
overall functioning in a large sample of euthymic patients with bipolar disorder in real‐life …

All psychiatric disorders have suffered from a dearth of truly novel pharmacological
interventions. In bipolar disorder, lithium remains a mainstay of treatment, six decades since …