Chondrogenesis of dedifferentiated chondrocytes and mesenchymal stem cells is influenced
not only by soluble molecules like growth factors, but also by the cell environment itself. The …

Extracellular matrix (ECM) acts as an instructing template for the cells contained in tissues. It
plays a vital role in regulating cellular behavior by holding and interacting with various …

Approaches to the design and construction of biomimetic scaffolds for osteochondral tissue,
show increasing advances. Considering the limitations of this tissue in terms of repair and …

In this study, we fabricate squeezable cryogel microbeads as injectable scaffolds for
minimum invasive delivery of chondrocytes for cartilage tissue engineering applications. The …

Osteoarthritis (OA) is a chronic degenerative joint disease characterized by the progressive
loss of articular cartilage, remodeling of the subchondral bone, and synovial inflammation …

Reactive oxygen species (ROS) refers to the reactive molecules and free radicals of oxygen
generated as the by-products of aerobic respiration. Historically, ROS are known as stress …

It is well known that biophysical properties of the extracellular matrix (ECM), including
stiffness, porosity, composition, and fiber alignment (anisotropy), play a crucial role in …

Due to the avascular nature of articular cartilage, damaged tissue has little capacity for
spontaneous healing. Three-dimensional scaffolds have potential for use in tissue …

Osteochondral structure reconstruction by tissue engineering, a challenge in regenerative
medicine, requires a scaffold that ensures both articular cartilage and subchondral bone …

The treatment of osteochondral defects remains challenging due to the limited healing
capacity of cartilage and the poor results of traditional methods. Inspired by the structure of …