Acute lung injury (ALI) and its more severe form, the acute respiratory distress syndrome
(ARDS), are syndromes of acute respiratory failure that result from acute pulmonary edema …

Magnesium is the second most abundant intracellular cation and the fourth most common
cation in the body [1]. Its importance as an essential nutrient has been recognized since …

Background: Pulmonary endothelium is an active organ possessing numerous
physiological, immunological, and metabolic functions. These functions may be altered early …

Objective: Pressure inflating the lung during mechanical ventilation is the difference
between pressure applied at the airway opening (P ao) and pleural pressure (P pl) …

Objective: To determine the association between body mass index (BMI) and hospital
mortality for critically ill adults. Design: Retrospective cohort study. Setting: One-hundred six …

Acute lung injury (ALI) is a severe illness with excess mortality and no specific therapy. In its
early exudative phase, neutrophil activation and accumulation in the lung lead to …

Rationale: Premature infants are exposed to potentially injurious ventilation in the delivery
room. Assessments of lung injury are confounded by effects of subsequent ventilatory …

Mechanical ventilation generates injurious forces that exacerbate lung injury. These forces
disrupt lung barrier integrity, trigger proinflammatory mediator release, and differentially …

A 55-year-old man is hospitalized with severe community-acquired pneumonia, and the
acute respiratory distress syndrome (ARDS) develops. The patient requires intubation and …

Nuclear factor erythroid 2-related factor (Nrf2) confers protection against cell death induced
by hyperoxia and other proapoptotic stimuli. Because phosphoinositide-3-kinase (PI3K)/Akt …