Positron emission tomography (PET) constitutes a functional imaging technique that is
harnessed to probe biological processes in vivo. PET imaging has been used to diagnose …

Immuno-positron emission tomography (immunoPET) is a paradigm-shifting molecular
imaging modality combining the superior targeting specificity of monoclonal antibody (mAb) …

The emerging inverse electron demand Diels–Alder (IEDDA) reaction stands out from other
bioorthogonal reactions by virtue of its unmatchable kinetics, excellent orthogonality and …

Standard cancer therapies sometimes fail to deliver chemotherapeutic drugs to tumor cells
in a safe and effective manner. Nanotechnology takes the lead in providing new therapeutic …

While the Staudinger reaction has first been described a hundred years ago in 1919, the
ligation reaction became one of the most important and efficient bioconjugation techniques …

Radiometals comprise many useful radioactive isotopes of various metallic elements. When
properly harnessed, these have valuable emission properties that can be used for …

The advancement of polymer science embraces the invention of molecular constructs that
provide functional applications. As a result, the development of novel methodologies for the …

Abstract The 2022 Nobel Prize in Chemistry was awarded to Professors K. Barry Sharpless,
Morten Meldal and Carolyn Bertozzi for their pioneering roles in the advent of click …

The advent of click chemistry has had a profound influence on almost all branches of
chemical science. This is particularly true of radiochemistry and the synthesis of agents for …

Intestinal homeostasis is tightly regulated by complex yet poorly understood signaling
networks. Here, we demonstrate that Lats1/2, the core Hippo kinases, are essential to …