Introduction: Ten years ago, we put forward the metabolo-oncogenic nature of fatty acid
synthase (FASN) in breast cancer. Since the conception of this hypothesis, which provided a …

Cancer therapy has long relied on the rapid proliferation of tumour cells for effective
treatment. However, the lack of specificity in this approach often leads to undesirable side …

Cancer cells characterized by uncontrolled growth and proliferation require altered
metabolic processes to maintain this characteristic. Metabolic reprogramming is a process …

Fatty acid synthase (FASN) is a key enzyme involved in neoplastic lipogenesis.
Overexpression of FASN is common in many cancers, and accumulating evidence suggests …

Dysregulation of cancer cell metabolism contributes to abnormal cell growth, the biological
end point of cancer. We review here numerous affected oncogenes and metabolic pathways …

Background Overexpression of the fatty acid synthase (FASN) gene has been implicated in
prostate carcinogenesis. We sought to directly assess the oncogenic potential of FASN …

Fatty acids are primary metabolites synthesized by complex, elegant, and essential
biosynthetic machinery. Fatty acid synthases resemble an iterative assembly line, with an …

Decades of preclinical and natural history studies have highlighted the potential of fatty acid
synthase (FASN) as a bona fide drug target for oncology. This review will highlight the …

Many tumors are dependent on de novo fatty acid synthesis to maintain cell growth. Fatty
acid synthase (FASN) catalyzes the final synthetic step of this pathway, and its upregulation …

Cancer cells synthesize de novo large amounts of fatty acids and cholesterol, irrespective of
the circulating lipid levels and benefit from this increased lipid synthesis in terms of growth …