Quadruplex nucleic acids as novel therapeutic targets
S Neidle - Journal of medicinal chemistry, 2016 - ACS Publications
Quadruplex-forming sequences are widely prevalent in human and other genomes,
including bacterial ones. These sequences are over-represented in eukaryotic telomeres …
including bacterial ones. These sequences are over-represented in eukaryotic telomeres …
Rationally engineered nucleic acid architectures for biosensing applications
Development of biosensing platforms plays a key role in research settings for identification
of biomarkers and in clinical applications for diagnostics. Biosensors based on nucleic acids …
of biomarkers and in clinical applications for diagnostics. Biosensors based on nucleic acids …
[HTML][HTML] From cascaded catalytic nucleic acids to enzyme–DNA nanostructures: controlling reactivity, sensing, logic operations, and assembly of complex structures
DNA is one of the most fascinating biopolymers. Besides its central role as carrier of genetic
information and translation of the genetic code into proteins, DNA holds great promise as a …
information and translation of the genetic code into proteins, DNA holds great promise as a …
Death and anti-death: tumour resistance to apoptosis
FH Igney, PH Krammer - Nature Reviews Cancer, 2002 - nature.com
Every cell in a multicellular organism has the potential to die by apoptosis, but tumour cells
often have faulty apoptotic pathways. These defects not only increase tumour mass, but also …
often have faulty apoptotic pathways. These defects not only increase tumour mass, but also …
Switching and signaling at the telomere
EH Blackburn - Cell, 2001 - cell.com
This review describes the structure of telomeres, the protective DNA-protein complexes at
eukaryotic chromosomal ends, and several molecular mechanisms involved in telomere …
eukaryotic chromosomal ends, and several molecular mechanisms involved in telomere …
G‐quartets 40 years later: from 5′‐GMP to molecular biology and supramolecular chemistry
JT Davis - Angewandte Chemie International Edition, 2004 - Wiley Online Library
Molecular self‐assembly is central to many processes in both biology and supramolecular
chemistry. The G‐quartet, a hydrogen‐bonded macrocycle formed by cation‐templated …
chemistry. The G‐quartet, a hydrogen‐bonded macrocycle formed by cation‐templated …
Human telomerase and its regulation
YS Cong, WE Wright, JW Shay - Microbiology and molecular …, 2002 - Am Soc Microbiol
The telomere is a special functional complex at the end of linear eukaryotic chromosomes,
consisting of tandem repeat DNA sequences and associated proteins. It is essential for …
consisting of tandem repeat DNA sequences and associated proteins. It is essential for …
The molecular biology of cancer
JS Bertram - Molecular aspects of medicine, 2000 - Elsevier
The process by which normal cells become progressively transformed to malignancy is now
known to require the sequential acquisition of mutations which arise as a consequence of …
known to require the sequential acquisition of mutations which arise as a consequence of …
[HTML][HTML] Biology of premature ageing in survivors of cancer
MC Cupit-Link, JL Kirkland, KK Ness, GT Armstrong… - ESMO open, 2017 - Elsevier
Over 30 million cancer survivors exist worldwide. Survivors have an earlier onset and higher
incidence of chronic comorbidities, including endocrinopathies, cardiac dysfunction …
incidence of chronic comorbidities, including endocrinopathies, cardiac dysfunction …