Melatonin, an indolamine mainly released from the pineal gland, is associated with many
biological functions, namely, the modulation of circadian and seasonal rhythms, sleep …

Background: Lifestyle and environmental factors can negatively impact fertility by means of
oxidative stress. In this context, antioxidant supplementation therapy has gained much …

Sertoli cells (SCs) provide structural and nutritional support for developing germ cells.
Normal glucose metabolism of SCs is necessary for spermatogenesis. Melatonin could …

The pineal hormone melatonin regulates testicular function through the hypothalamic-
adenohypophyseal axis. In addition, direct actions of melatonin in somatic cells of the testis …

Melatonin is a well-known, nighttime-produced indole found in bacteria, eukaryotic
unicellulars, animals or vascular plants. In vertebrates, melatonin is the major product of the …

Circadian rhythms are cyclic patterns of physiological, behavioural and molecular events
that occur over a 24-h period. They are controlled by the suprachiasmatic nucleus (SCN) …

Antioxidant actions of melatonin and its impact on testicular function and fertility have
already been described. Considering that Sertoli cells contribute to provide structural …

Simple Summary Animal reproduction is closely related to economic benefits and food
safety in domestic animals, as well as human fertility. There are many factors that affect the …

The blood-testicular barrier (BTB) is involved in spermatogenesis, protects sperm
development, and plays a crucial role in the reproductive process. Tight junctions (TJs) …

Melatonin co-operates with insulin in the regulation of glucose homeostasis. Within the
testis, glucose metabolism in the somatic Sertoli cells (SCs) is pivotal for spermatogenesis …