In the context of the coronavirus disease 2019 (COVID-19) pandemic, the global healthcare
community has raced to find effective therapeutic agents against severe acute respiratory …

Neonatal chronic lung disease, also known as bronchopulmonary dysplasia (BPD), is the
most common complication of premature birth, affecting up to 30% of very low birth weight …

Heart failure is one of the leading causes of death in the Western world. Glucocorticoids are
primary stress hormones that regulate a vast array of biological processes, and synthetic …

Glucocorticoids and their synthetic derivatives are known to alter cardiac function in vivo;
however, the nature of these effects and whether glucocorticoids act directly on …

Epidemiologic studies have linked intrauterine growth restriction (IUGR) with an increased
incidence of cardiovascular disease later in life; reduced cardiomyocyte number in IUGR …

Oil and natural gas operations have been shown to contaminate surface and ground water
with endocrine-disrupting chemicals. In the current study, we fill several gaps in our …

Insulin resistance is viewed as an insufficiency in insulin action, with glucocorticoids being
recognized to play a key role in its pathogenesis. With insulin resistance, metabolism in …

Background Premature birth is associated with ventricular remodeling, early heart failure,
and altered left ventricular (LV) response to physiological stress. Using computational …

Preterm birth coincides with a key developmental window of cardiac growth and maturation,
and thus has the potential to influence long-term cardiac function. Individuals born preterm …

The therapeutic potential for manipulation of glucocorticoid metabolism in cardiovascular
disease was revolutionized by the recognition that access of glucocorticoids to their …