The prevalence of diabetes is continuously increasing in the recent decades. Persistent
hyperglycemia, hyperinsulinemia and the subsequent oxidative stress result in diabetic …

One of the major challenges of cardiovascular primary prevention approach is the absence
of early biomarkers of endothelial dysfunction which may be useful for identifying at-risk …

The human sirtuins are a group of NAD+-dependent protein deacylases. They “erase” acyl
modifications from lysine residues in various cellular targets including histones, transcription …

Biological targeting or molecular targeting is the main strategy in drug development and
disease prevention. However, the problem of “off-targets” cannot be neglected. Naturally …

Background: Resveratrol is a polyphenol chemical that naturally occurs in many plant-based
dietary products, most notably, red wine. Discovered in 1939, widespread interest in the …

The currently available anti-obesity therapies encounter many associated risks and side
effects often causing the ineffectiveness of treatment. Therefore, various plant-derived …

Tumor resistance to therapy modalities is one of the major challenges to the eradication of
cancer cells and complete treatment. Tumor includes a wide range of cancer and non …

Conventional cancer treatment is mainly based on the surgical removal of the tumor
followed by radiotherapy and/or chemotherapy. When surgical removal is not possible …

Obesity is a widespread disease that is associated with numerous and serious
comorbidities. These include metabolic syndrome, diabetes mellitus, cardiovascular …

Diabetes mellitus (DM) is a chronic, progressive, and multifaceted illness resulting in
significant physical and psychological detriment to patients. As of 2019, 463 million people …