Cell type–specific three-dimensional structure of thalamocortical circuits in a column of rat vibrissal cortex
Soma location, dendrite morphology, and synaptic innervation may represent key
determinants of functional responses of individual neurons, such as sensory-evoked spiking …
determinants of functional responses of individual neurons, such as sensory-evoked spiking …
Three-dimensional axon morphologies of individual layer 5 neurons indicate cell type-specific intracortical pathways for whisker motion and touch
M Oberlaender, ZSRM Boudewijns… - Proceedings of the …, 2011 - National Acad Sciences
The cortical output layer 5 contains two excitatory cell types, slender-and thick-tufted
neurons. In rat vibrissal cortex, slender-tufted neurons carry motion and phase information …
neurons. In rat vibrissal cortex, slender-tufted neurons carry motion and phase information …
Sensory experience restructures thalamocortical axons during adulthood
The brain's capacity to rewire is thought to diminish with age. It is widely believed that
development stabilizes the synapses from thalamus to cortex and that adult experience …
development stabilizes the synapses from thalamus to cortex and that adult experience …
A survey of visualization and analysis in high‐resolution connectomics
The field of connectomics aims to reconstruct the wiring diagram of Neurons and synapses
to enable new insights into the workings of the brain. Reconstructing and analyzing the …
to enable new insights into the workings of the brain. Reconstructing and analyzing the …
3D reconstruction and standardization of the rat vibrissal cortex for precise registration of single neuron morphology
The three-dimensional (3D) structure of neural circuits is commonly studied by
reconstructing individual or small groups of neurons in separate preparations. Investigation …
reconstructing individual or small groups of neurons in separate preparations. Investigation …
The Filament Editor: an interactive software environment for visualization, proof-editing and analysis of 3D neuron morphology
VJ Dercksen, HC Hege, M Oberlaender - Neuroinformatics, 2014 - Springer
Neuroanatomical analysis, such as classification of cell types, depends on reliable
reconstruction of large numbers of complete 3D dendrite and axon morphologies. At …
reconstruction of large numbers of complete 3D dendrite and axon morphologies. At …
Automated stitching of microtubule centerlines across serial electron tomograms
Tracing microtubule centerlines in serial section electron tomography requires microtubules
to be stitched across sections, that is lines from different sections need to be aligned …
to be stitched across sections, that is lines from different sections need to be aligned …
An anterograde rabies virus vector for high-resolution large-scale reconstruction of 3D neuron morphology
MG Haberl, S Viana da Silva, JM Guest… - Brain Structure and …, 2015 - Springer
Glycoprotein-deleted rabies virus (RABV∆ G) is a powerful tool for the analysis of neural
circuits. Here, we demonstrate the utility of an anterograde RABV∆ G variant for novel …
circuits. Here, we demonstrate the utility of an anterograde RABV∆ G variant for novel …
Simulation of signal flow in 3D reconstructions of an anatomically realistic neural network in rat vibrissal cortex
S Lang, VJ Dercksen, B Sakmann, M Oberlaender - Neural Networks, 2011 - Elsevier
The three-dimensional (3D) structure of neural circuits represents an essential constraint for
information flow in the brain. Methods to directly monitor streams of excitation, at subcellular …
information flow in the brain. Methods to directly monitor streams of excitation, at subcellular …
Fast assembling of neuron fragments in serial 3D sections
Reconstructing neurons from 3D image-stacks of serial sections of thick brain tissue is very
time-consuming and often becomes a bottleneck in high-throughput brain mapping projects …
time-consuming and often becomes a bottleneck in high-throughput brain mapping projects …