Biochemistry, cell biology, and pathophysiology of the innate immune cGAS–cGAMP–STING pathway
In the decade since the discovery of the innate immune cyclic GMP–AMP synthase (cGAS)–
2′ 3′-cyclic GMP–AMP (cGAMP)–stimulator of interferon genes (STING) pathway, its …
2′ 3′-cyclic GMP–AMP (cGAMP)–stimulator of interferon genes (STING) pathway, its …
cGAMP the travelling messenger
HTW Blest, L Chauveau - Frontiers in Immunology, 2023 - frontiersin.org
2'3'-cGAMP is a key molecule in the cGAS-STING pathway. This cyclic dinucleotide is
produced by the cytosolic DNA sensor cGAS in response to the presence of aberrant dsDNA …
produced by the cytosolic DNA sensor cGAS in response to the presence of aberrant dsDNA …
ENPP1 is an innate immune checkpoint of the anticancer cGAMP–STING pathway in breast cancer
Ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) expression correlates with
poor prognosis in many cancers, and we previously discovered that ENPP1 is the dominant …
poor prognosis in many cancers, and we previously discovered that ENPP1 is the dominant …