Microtubules are essential dynamic polymers composed of α/β-tubulin heterodimers. They
support intracellular trafficking, cell division, cellular motility, and other essential cellular …

The inter-neuronal communication occurring in extensively branched neuronal cells is
achieved primarily through the microtubule (MT)-mediated axonal transport system. This …

Microtubules play crucial roles in cellular architecture, intracellular transport, and mitosis.
The availability of free tubulin subunits affects polymerization dynamics and microtubule …

Tubulin posttranslational modifications represent an important mechanism involved in the
regulation of microtubule functions. The most widespread among them are detyrosination …

Microtubules, a critical component of the cytoskeleton, carry post-translational modifications
(PTMs) that are important for the regulation of key cellular processes. Long-lived …

Compounds targeting microtubules are widely used in cancer therapy with a proven efficacy.
However, because they also target non-cancerous cells, their administration leads to …

Regulation of directed axon guidance and branching during development is essential for the
generation of neuronal networks. However, the molecular mechanisms that underlie …

α/β-Tubulin posttranslational modifications (PTMs) generate microtubule diversity, but
whether they account for cancer cell resistance to microtubule-targeting drugs remains …

To initiate directed movement, cells must become polarized, establishing a protrusive
leading edge and a contractile trailing edge. This symmetry-breaking process involves …

Tubulin post-translational modifications (PTMs) alter microtubule properties by affecting the
binding of microtubule-associated proteins (MAPs). Microtubule detyrosination, which …