Getting into the brain: liposome-based strategies for effective drug delivery across the blood–brain barrier

DB Vieira, LF Gamarra - International journal of nanomedicine, 2016 - Taylor & Francis
This review summarizes articles that have been reported in literature on liposome-based
strategies for effective drug delivery across the blood–brain barrier. Due to their unique …

Nanoparticles and targeted drug delivery in cancer therapy

B Bahrami, M Hojjat-Farsangi, H Mohammadi… - Immunology letters, 2017 - Elsevier
Surgery, chemotherapy, radiotherapy, and hormone therapy are the main common anti-
tumor therapeutic approaches. However, the non-specific targeting of cancer cells has made …

Vasculogenic mimicry signaling revisited: focus on non-vascular VE-cadherin

D Delgado-Bellido, S Serrano-Saenz… - Molecular cancer, 2017 - Springer
Vasculogenic mimicry (VM) is a blood supply system independent of endothelial vessels in
tumor cells from different origins. It reflects the plasticity of aggressive tumor cells that …

Targeted nanomedicine for cancer therapeutics: Towards precision medicine overcoming drug resistance

M Bar-Zeev, YD Livney, YG Assaraf - Drug Resistance Updates, 2017 - Elsevier
Intrinsic anticancer drug resistance appearing prior to chemotherapy as well as acquired
resistance due to drug treatment, remain the dominant impediments towards curative cancer …

Tailoring particle size of mesoporous silica nanosystem to antagonize glioblastoma and overcome blood–brain barrier

J Mo, L He, B Ma, T Chen - ACS applied materials & interfaces, 2016 - ACS Publications
The blood–brain barrier (BBB) is the main bottleneck to prevent some macromolecular
substance entering the cerebral circulation, resulting the failure of chemotherapy in the …

RGD-modified polymer and liposome nanovehicles: Recent research progress for drug delivery in cancer therapeutics

Y Cheng, Y Ji - European journal of pharmaceutical sciences, 2019 - Elsevier
Over the past few decades, as the demand for cancer treatment has increased, more rational
treatment options (considering size, mode of administration, biocompatibility, efficacy, etc.) …

Targeted theranostic nanoparticles for brain tumor treatment

M Mendes, JJ Sousa, A Pais, C Vitorino - Pharmaceutics, 2018 - mdpi.com
The poor prognosis and rapid recurrence of glioblastoma (GB) are associated to its fast-
growing process and invasive nature, which make difficult the complete removal of the …

[HTML][HTML] Targeting cancer stem cells in drug discovery: Current state and future perspectives

FY Du, QF Zhou, WJ Sun, GL Chen - World journal of stem cells, 2019 - ncbi.nlm.nih.gov
In recent decades, cancer stem cells (CSCs) have been increasingly identified in many
malignancies. CSC-related signaling pathways and their functions provide new strategies …

Overview of advances in vasculogenic mimicry–a potential target for tumor therapy

H Ge, H Luo - Cancer management and research, 2018 - Taylor & Francis
Vasculogenic mimicry (VM) describes the process utilized by highly aggressive cancer cells
to generate vascular-like structures without the presence of endothelial cells. VM has been …

Surface modification of lipid-based nanocarriers for cancer cell-specific drug targeting

CH Kim, SG Lee, MJ Kang, S Lee, YW Choi - Journal of Pharmaceutical …, 2017 - Springer
Targeted drug delivery systems using nanocarriers for anticancer drugs have been
investigated for over several decades. Among the many nanocarrier systems, lipid-based …