Protein-protein interactions are essential for the assembly, regulation, and localization of
functional protein complexes in the cell. SAM domains are among the most abundant protein …

The ETV6 (also known as TEL) gene encodes a transcriptional repressor that plays a critical
role in hematopoiesis and in embryonic development. While somatic ETV6 translocations …

The Janus family of tyrosine kinases (JAK) plays an essential role in development and in
coupling cytokine receptors to downstream intracellular signaling events. A t (9; 12)(p24; …

The EWS-FLI1 fusion oncoprotein deregulates transcription to initiate the paediatric cancer
Ewing sarcoma. Here we used a domain-focused CRISPR screen to implicate the …

Chromosome translocations involving band 12p13 are known to be involved in a variety of
hematologic malignancies, some of them resulting in rearrangement of the ETV6/TEL gene …

The TEL gene, which is frequently rearranged in human leukemias of both myeloid and
lymphoid origin, encodes a member of the Ets family of transcription factors. The TEL gene is …

Sequence-specific DNA binding proteins that function as transcription factors are frequently
encoded by gene families. Such proteins display highly conserved DNA binding properties …

Transcription factors provide nodes of information integration by serving as nuclear effectors
of multiple signaling cascades, and thus elaborate layers of regulation, often involving post …

Alterations of the ets family transcription factor ETV6 (TEL) and the RUNT domain
transcription factor RUNX1 (AML1) play pivotal roles in the leukemogenesis of various types …

Recent reports have demonstrated fusion of the TEL gene on 12p13 to the JAK2 gene on
9p24 in human leukemias. Three variants have been identified that fuse the TEL pointed …