In the past decade, multicomponent reactions have experienced a renaissance as powerful
peptide macrocyclization tools enabling the rapid creation of skeletal complexity and …

Macrocyclic structures are common synthetic targets in drug discovery,(1, 2) and therefore,
interest in their study is continuously increasing in this field.(3, 4) A classic example is …

Peptide macrocycles have found applications that range from drug discovery to
nanomaterials. These ring-shaped molecules have shown remarkable capacity for …

This protocol presents a detailed description of the synthesis of N-methylated cyclic
peptides. N-methylation is a powerful technique to modulate the physicochemical properties …

Here, we report a novel “CyClick” strategy for the macrocyclization of peptides that works in
an exclusively intramolecular fashion thereby precluding the formation of dimers and …

Small cyclic peptides possess a wide range of biological properties and unique structures
that make them attractive to scientists working in a range of areas from medicinal to …

Halogen bonding is a weak chemical force that has so far mostly found applications in
crystal engineering. Despite its potential for use in drug discovery, as a new molecular tool …

Head-to-tail cyclic peptides exhibit remarkable biological activities with extraordinary
potency and oral-bioavailability owing to their compacted structures and high stability …

Protected peptide fragments are valuable building blocks for the assembly of large peptide
sequences through fragment condensation approaches, whereas protected peptides are …

Helicobacter pylori is a specific gastric pathogen that colonizes the stomach in more than
50% of the world's human population. Infection with this bacterium can induce several types …