Current medication for anxiety disorders is suboptimal in terms of efficiency and tolerability,
highlighting the need for improved drug treatments. In this review an overview of drugs …

Introduction: Anxiety disorders are among the most prevalent and disabling psychiatric
disorders in the United States and worldwide. Basic research has provided critical insights …

Background Gamma-aminobutyric acid A (GABA A) receptors have been implicated in
anxiety and epileptic disorders. Hypothesis/Purpose This study aimed to investigate the …

Brain-derived neurotrophic factor (BDNF) is a neurotrophin that serves as a survival factor
for neurons. Agomelatine is a novel antidepressant as well as a potent agonist of melatonin …

Background: Agomelatine modulates brain-derived neurotrophic factor expression via its
interaction with melatonergic and serotonergic receptors and has shown promising results in …

G protein coupled receptors (GPCRs) are the main mediators of signal transduction in the
central nervous system. Therefore, it is not surprising that many GPCRs have long been …

The potential use of agomelatine as an alternative treatment for colorectal cancer is
evaluated in this work. The effect of agomelatine was studied in an in vitro model using two …

Abstract Huntington's disease (HD), a devastating neurodegenerative disorder, is
characterized by progressive motor dysfunction, emotional disturbances, dementia, weight …

Agomelatine, a melatonergic antidepressant with a rapid onset of action, is one of the most
recent drugs in the antidepressant category. Agomelatine's antidepressant actions are …

Melatonin exerts its actions through membrane MT1/MT2 melatonin receptors, which belong
to the super family of G-protein-coupled receptors consisting of the typical seven …