The robotic mouse: unravelling the function of AF4 in the cerebellum
The devastating nature and lack of effective treatments associated with neurodegenerative
diseases have stimulated a world-wide search for the elucidation of their molecular basis to …
diseases have stimulated a world-wide search for the elucidation of their molecular basis to …
Hox Genes and Their Candidate Downstream Targets in the Developing Central Nervous System
ZN Akin, AJ Nazarali - Cellular and molecular neurobiology, 2005 - Springer
Homeobox (Hox) genes were originally discovered in the fruit fly Drosophila, where they
function through a conserved homeodomain as transcriptional regulators to control …
function through a conserved homeodomain as transcriptional regulators to control …
Systematic expression analysis of Hox genes at adulthood reveals novel patterns in the central nervous system
B Hutlet, N Theys, C Coste, MT Ahn… - Brain Structure and …, 2016 - Springer
Hox proteins are key regulators of animal development, providing positional identity and
patterning information to cells along the rostrocaudal axis of the embryo. Although their …
patterning information to cells along the rostrocaudal axis of the embryo. Although their …
The cerebellar transcriptome during postnatal development of the Ts1Cje mouse, a segmental trisomy model for Down syndrome
L Dauphinot, R Lyle, I Rivals, MT Dang… - Human molecular …, 2005 - academic.oup.com
The central nervous system of persons with Down syndrome presents cytoarchitectural
abnormalities that likely result from gene-dosage effects affecting the expression of key …
abnormalities that likely result from gene-dosage effects affecting the expression of key …
[HTML][HTML] Identification of transcriptional targets of HOXA5
H Chen, E Rubin, H Zhang, S Chung, CC Jie… - Journal of Biological …, 2005 - ASBMB
The homeobox gene HOXA5 encodes a transcription factor that has been shown to play
important roles in embryogenesis, hematopoiesis, and tumorigenesis. In order to decipher …
important roles in embryogenesis, hematopoiesis, and tumorigenesis. In order to decipher …
[HTML][HTML] The ciliary Frizzled-like receptor Tmem67 regulates canonical Wnt/β-catenin signalling in the developing cerebellum via Hoxb5
ZA Abdelhamed, DI Abdelmottaleb, ME El-Asrag… - Scientific reports, 2019 - nature.com
Primary cilia defects result in a group of related pleiotropic malformation syndromes known
as ciliopathies, often characterised by cerebellar developmental and foliation defects. Here …
as ciliopathies, often characterised by cerebellar developmental and foliation defects. Here …
Selective disruption of “late onset” sagittal banding patterns by ectopic expression of engrailed-2 in cerebellar Purkinje cells
SL Baader, MW Vogel, S Sanlioglu… - Journal of …, 1999 - Soc Neuroscience
To explore the role of Engrailed proteins in development of the cerebellum, Engrailed-2 (En-
2) was ectopically expressed in cerebellar Purkinje cells from the late embryonic stage into …
2) was ectopically expressed in cerebellar Purkinje cells from the late embryonic stage into …
[HTML][HTML] Conditional Loss of Hoxa5 Function Early after Birth Impacts on Expression of Genes with Synaptic Function
B Lizen, C Moens, J Mouheiche, T Sacré… - Frontiers in Molecular …, 2017 - frontiersin.org
Hoxa5 is a member of the Hox gene family that plays critical roles in successive steps of the
central nervous system formation during embryonic and fetal development. In the mouse …
central nervous system formation during embryonic and fetal development. In the mouse …
HOXA5 localization in postnatal and adult mouse brain is suggestive of regulatory roles in postmitotic neurons
B Lizen, B Hutlet, D Bissen… - Journal of …, 2017 - Wiley Online Library
Hoxa5 is a member of the Hox gene family, which plays critical roles in successive steps of
the central nervous system formation during embryonic and fetal development. Hoxa5 …
the central nervous system formation during embryonic and fetal development. Hoxa5 …
Engrailed‐2 negatively regulates the onset of perinatal Purkinje cell differentiation
J Jankowski, MI Holst, C Liebig… - Journal of …, 2004 - Wiley Online Library
The transcription factor Engrailed‐2 is expressed in cerebellar Purkinje cells (PCs)
throughout embryonic development but is downregulated in PCs after birth. Since the onset …
throughout embryonic development but is downregulated in PCs after birth. Since the onset …