The devastating nature and lack of effective treatments associated with neurodegenerative
diseases have stimulated a world-wide search for the elucidation of their molecular basis to …

Homeobox (Hox) genes were originally discovered in the fruit fly Drosophila, where they
function through a conserved homeodomain as transcriptional regulators to control …

Hox proteins are key regulators of animal development, providing positional identity and
patterning information to cells along the rostrocaudal axis of the embryo. Although their …

The central nervous system of persons with Down syndrome presents cytoarchitectural
abnormalities that likely result from gene-dosage effects affecting the expression of key …

The homeobox gene HOXA5 encodes a transcription factor that has been shown to play
important roles in embryogenesis, hematopoiesis, and tumorigenesis. In order to decipher …

Primary cilia defects result in a group of related pleiotropic malformation syndromes known
as ciliopathies, often characterised by cerebellar developmental and foliation defects. Here …

To explore the role of Engrailed proteins in development of the cerebellum, Engrailed-2 (En-
2) was ectopically expressed in cerebellar Purkinje cells from the late embryonic stage into …

Hoxa5 is a member of the Hox gene family that plays critical roles in successive steps of the
central nervous system formation during embryonic and fetal development. In the mouse …

Hoxa5 is a member of the Hox gene family, which plays critical roles in successive steps of
the central nervous system formation during embryonic and fetal development. Hoxa5 …

The transcription factor Engrailed‐2 is expressed in cerebellar Purkinje cells (PCs)
throughout embryonic development but is downregulated in PCs after birth. Since the onset …