The multifaceted roles of copper in cancer: A trace metal element with dysregulated metabolism, but also a target or a bullet for therapy

P Lelièvre, L Sancey, JL Coll, A Deniaud, B Busser - Cancers, 2020 - mdpi.com
Simple Summary Copper is an essential element for human life. However, its redox activity
can be detrimental for the cell that developed highly coordinated pathways to chelate and …

Promising natural products in new drug design, development, and therapy for skin disorders: An overview of scientific evidence and understanding their mechanism of …

NA Mohd Zaid, M Sekar, SR Bonam… - Drug design …, 2023 - Taylor & Francis
The skin is the largest organ in the human body, composed of the epidermis and the dermis.
It provides protection and acts as a barrier against external menaces like allergens …

Novel quercetin encapsulated chitosan functionalized copper oxide nanoparticles as anti-breast cancer agent via regulating p53 in rat model

AM Elsayed, NM Sherif, NS Hassan, F Althobaiti… - International Journal of …, 2021 - Elsevier
This study was designed to present a new quercetin encapsulated chitosan functionalized
copper oxide nanoparticle (CuO-ChNPs-Q) and assessed its anti-breast cancer activity both …

Quercetin in cancer treatment, alone or in combination with conventional therapeutics?

A Filipa Brito, M Ribeiro… - Current medicinal …, 2015 - ingentaconnect.com
Cancer is a problem of global importance, since the incidence is increasing worldwide and
therapeutic options are generally limited. Thus, it becomes imperative to find new …

Sensors for diagnosis of prostate cancer: Looking beyond the prostate specific antigen

C Dejous, UM Krishnan - Biosensors and Bioelectronics, 2021 - Elsevier
Prostate cancer represents one of the most common forms of cancer affecting men across
the globe. Due to late diagnosis of this disease, the mortality of this condition is very high …

Structure-Based Virtual Screening of Furan-1,3,4-Oxadiazole Tethered N-phenylacetamide Derivatives as Novel Class of hTYR and hTYRP1 Inhibitors

A Irfan, S Faisal, S Ahmad, SA Al-Hussain, S Javed… - pharmaceuticals, 2023 - mdpi.com
Human tyrosinase (hTYR) is a key and rate-limiting enzyme along with human tyrosinase-
related protein-1 (hTYRP1), which are among the most prominent targets of inhibiting hyper …

Inducers of senescence, toxic compounds, and senolytics: The multiple faces of Nrf2‐activating phytochemicals in cancer adjuvant therapy

M Malavolta, M Bracci, L Santarelli… - Mediators of …, 2018 - Wiley Online Library
The reactivation of senescence in cancer and the subsequent clearance of senescent cells
are suggested as therapeutic intervention in the eradication of cancer. Several natural …

Highly selective fluorescent probe based on hydroxylation of phenylboronic acid pinacol ester for detection of tyrosinase in cells

H Li, W Liu, F Zhang, X Zhu, L Huang… - Analytical …, 2018 - ACS Publications
The detection of tyrosinase, a biomarker for melanoma, is of great significance. Herein, a
fluorescent tyrosinase probe, with resorufin as the fluorophore and m-tolylboronic acid …

Pathology and Molecular Biology of Melanoma

T Timis, JT Bergthorsson, V Greiff, M Cenariu… - Current Issues in …, 2023 - mdpi.com
Almost every death in young patients with an advanced skin tumor is caused by melanoma.
Today, with the help of modern treatments, these patients survive longer or can even …

[HTML][HTML] Preclinical validation of a new hybrid molecule loaded in liposomes for melanoma management

JO Pinho, M Matias, V Marques, C Eleutério… - Biomedicine & …, 2023 - Elsevier
The aggressiveness of melanoma and lack of effective therapies incite the discovery of
novel strategies. Recently, a new dual acting hybrid molecule (HM), combining a triazene …