Protein‐protein interaction plays key role in predicting the protein function of target protein
and drug ability of molecules. The majority of genes and proteins realize resulting …

In the last century, small-molecule natural products were the main inspiration for most drug
discovery programs based either on high-throughput screening (HTS) or rational design …

The yeast two-hybrid system pioneered the field of in vivo protein-protein interaction
methods and undisputedly gave rise to a palette of ingenious techniques that are constantly …

Almost all the cellular processes in a living system are controlled by proteins: They regulate
gene expression, catalyze chemical reactions, transport small molecules across …

Highlights•Split biosensor assays allow monitoring of dynamic protein–protein interactions
in cell-based assays.•The activity of druggable targets, such as GPCRs and RTKs, can be …

The 14-3-3 proteins are a family of ubiquitous and exclusively eukaryotic proteins with an
astoundingly significant number of binding partners. Their binding alters the activity, stability …

Signal transduction is the primary process by which cells respond to changes in their
physical and chemical environments. Cellular response is initiated through a signaling …

Kinases play fundamental roles in the brain. Through complex signaling pathways, kinases
regulate the strength of protein: protein interactions (PPI) influencing cell cycle, signal …

Protein–protein interaction networks are mathematical constructs where every protein is
represented as a node, with an edge signaling that two proteins interact. These constructs …

Upregulation of the proto-oncogene T-cell leukemia/lymphoma 1A (TCL1A) is causally
implicated in various B-cell and T-cell malignancies. High-level TCL1A correlates with …